| A longitudinal observational study of brain atrophy rate reflecting four decades of multiple sclerosis: a comparison of serial 1D, 2D, and volumetric measurements from MRI images. | |
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MedLine Citation:
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PMID: 19774369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Multiple sclerosis (MS) has a variable progression with an early onset of atrophy. Individual longitudinal radiological evaluations (over decades) are difficult to perform due to the limited availability of magnetic resonance imaging (MRI) in the past, patients lost in follow-up, and the continuous updating of scanners. We studied a cohort with widespread disease duration at baseline. The observed individual atrophy rates over time of 10 years represented four decades of disease span. METHODS: Thirty-seven MS patients (age range 24-65 years with disease duration 1-33 years) were consecutively selected and evaluated with MRI at baseline 1995 and in 1996. They were followed up for a decade (mean of 9.25 years, range 7.3-10 years) up to 2003-2005. Brain parenchymal volume and volumes of the supratentorial ventricles were analyzed with semi-automated volumetric measurements at three time points (1995, 1996, and 2003-2005). RESULTS: Volumetric differences were found over shorter periods of time (1-7 months); however, differences vanished by the end of follow-up. A uniform longitudinal decrease in brain volume and increase in ventricle volumes were found. Frontal horn width (1D) correlated strongest to 3D measures. No statistical differences of atrophy rates between MS courses were found. Supratentorial ventricular volumes were associated with disability and this association persisted during follow-up. CONCLUSION: Despite variable clinical courses, the degenerative effects of MS progression expressed in brain atrophy seem to uniformly progress over longer periods of time. These volumetric changes can be detected using 1D and 2D measurements performed on a routine PACS workstation. |
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Authors:
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Juha Martola; Jakob Bergstr?m; Sten Fredrikson; Leszek Stawiarz; Jan Hillert; Yi Zhang; Olof Flodmark; Anders Lilja; Anders Ekbom; Peter Aspelin; Maria Kristoffersen Wiberg |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-09-23 |
Journal Detail:
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Title: Neuroradiology Volume: 52 ISSN: 1432-1920 ISO Abbreviation: Neuroradiology Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 109-17 Citation Subset: IM |
Affiliation:
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Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, 14186 Stockholm, Sweden. juha.martola@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / pathology* Atrophy Brain / pathology* Cerebral Ventricles / pathology Disability Evaluation Disease Progression Female Follow-Up Studies Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional / methods Longitudinal Studies Magnetic Resonance Imaging / methods* Male Middle Aged Multiple Sclerosis / pathology* Organ Size Time Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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