Document Detail


A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis.
MedLine Citation:
PMID:  20809047     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymyositis and dermatomyositis are orphan, chronic skeletal muscle disorders characterized by weakness, infiltrations by mononuclear inflammatory cells, and fibrosis. Until recently, patients were advised to refrain from physical activity because of fears of exacerbation of muscle inflammation. However, recent studies have shown that moderate exercise training in combination with immunosuppressive drugs can improve muscle performance. Despite the positive effects of exercise training, the molecular mechanisms underlying the exercise-associated clinical improvements remain poorly understood. The present study was designed to define, at the molecular level, the effects of resistance exercise training on muscle performance and disease progression in myositis patients. We evaluated changes in muscle strength, histology and genome-wide mRNA profiles to determine the beneficial effects of exercise and determine the possible molecular changes associated with improved muscle performance. A total of 8 myositis patients underwent a 7-wk resistance exercise training program that resulted in improved muscle strength and increased maximal oxygen uptake (VO(2max)). Training also resulted in marked reductions in gene expression, reflecting reductions in proinflammatory and profibrotic gene networks, changes that were also accompanied by a reduction in tissue fibrosis. Consistent with the exercise-associated increase in VO(2max), a subset of transcripts was associated with a shift toward oxidative metabolism. The changes in gene expression reported in the present study are in agreement with the performance improvements induced by exercise and suggest that resistance exercise training can induce a reduction in inflammation and fibrosis in skeletal muscle.
Authors:
Gustavo A Nader; Maryam Dastmalchi; Helene Alexanderson; Cecilia Grundtman; Ramkishore Gernapudi; Mona Esbjörnsson; Zuyi Wang; Johan Rönnelid; Eric P Hoffman; Kanneboyina Nagaraju; Ingrid E Lundberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-16
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  16     ISSN:  1528-3658     ISO Abbreviation:  Mol. Med.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-05     Completed Date:  2011-02-17     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Fibrosis / metabolism
Gene Expression Profiling*
Glucocorticoids / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Inflammation / metabolism
Longitudinal Studies
Middle Aged
Muscle Strength*
Muscle, Skeletal / metabolism
Myositis / therapy*
Oxygen Consumption / physiology
RNA, Messenger / metabolism*
Resistance Training*
Grant Support
ID/Acronym/Agency:
1U54HD053177/HD/NICHD NIH HHS; 3R01-NS29525-13/NS/NINDS NIH HHS; 5R24HD050846/HD/NICHD NIH HHS; NS-029525/NS/NINDS NIH HHS; R01-AR050478/AR/NIAMS NIH HHS; R24 HD050846/HD/NICHD NIH HHS; R24 HD050846-07/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 0/RNA, Messenger
Comments/Corrections

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