| A longitudinal genetic study of plasma lipids in adolescent twins. | |
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MedLine Citation:
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PMID: 17539372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma lipids such as high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol and triglyceride levels contribute to variation in the risk of cardiovascular disease. The early stages of atherosclerosis in childhood have also been associated with changes in triglycerides, LDL and HDL. Heritability estimates for lipids and lipoproteins for adolescents are in the range .71 to .82, but little is known about changes of genetic and environmental influences over time in adolescence. We have investigated the contribution of genetic and environmental influences to variation in lipids in adolescent twins and their nontwin siblings using longitudinal twin and family data. Plasma HDL and LDL cholesterol, total cholesterol and triglycerides data from 965 twin pairs at 12, 14 and 16 years of age and their siblings have been analyzed. Longitudinal genetic models that included effects of age, sex and their interaction were fitted to assess whether the same or different genes influence each trait at different ages. Results suggested that more than one genetic factor influences HDL, LDL, total cholesterol and triglycerides over time at ages 12, 14 and 16 years. There was no evidence of shared environmental effects except for HDL and little evidence of long-term nonshared environmental effects was found. Our study suggested that there are developmental changes in the genes affecting plasma lipid concentrations across adolescence. |
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Authors:
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Rita P S Middelberg; Nicholas G Martin; John B Whitfield |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 10 ISSN: 1832-4274 ISO Abbreviation: - Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-06-01 Completed Date: 2007-07-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
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Languages: eng Pagination: 127-35 Citation Subset: IM |
Affiliation:
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Genetic Epidemiology Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia. rita.middelberg@qimr.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Development* Age Factors Cardiovascular Diseases / blood, genetics Child Cholesterol / blood*, genetics Female Humans Lipoproteins, HDL / blood*, genetics Lipoproteins, LDL / blood*, genetics Longitudinal Studies Male Models, Genetic Sex Factors Time Factors Triglycerides / blood*, genetics Twins / blood*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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