Document Detail

Is long-term treatment of Alzheimer's disease with cholinesterase inhibitor therapy justified?
MedLine Citation:
PMID:  17953456     Owner:  NLM     Status:  MEDLINE    
The cholinesterase inhibitors (ChEIs) donepezil, rivastigmine and galantamine are the current mainstays in the drug treatment of Alzheimer's disease (AD). There is convincing evidence that these agents provide at least modest cognitive, behavioural and functional benefit for 6-12 months at all stages of the disease. Longer term benefits cannot be directly examined by placebo-controlled trials. Nevertheless, the results of virtually all open-label extensions of the pivotal trials, studies of patients with AD at different levels of severity and clinical trials using other designs favour treatment over no treatment for periods of up to 5 years. There are plausible biological reasons why ChEIs might be expected to work over a prolonged period of time although, to date, studies using various markers to chart the effects of medication on long-term disease progression have yielded mixed results. The most contentious issue regarding long-term treatment is economic, but the majority of available economic analyses suggest net savings over the long term if patients with AD receive persistent treatment with ChEIs.
Ben Seltzer
Related Documents :
20586956 - Patient retention in antiretroviral therapy programs up to three years on treatment in ...
22279356 - Retrieval of proximally migrated double j ureteric stents in children using goose neck ...
14754826 - Patient education to encourage graded exercise in chronic fatigue syndrome. 2-year foll...
20825986 - Effect of celiprolol on prevention of cardiovascular events in vascular ehlers-danlos s...
12724676 - Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year f...
12032716 - Visual acuity outcomes following vitreous loss in glaucoma and diabetic patients.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs & aging     Volume:  24     ISSN:  1170-229X     ISO Abbreviation:  Drugs Aging     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102074     Medline TA:  Drugs Aging     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  881-90     Citation Subset:  IM    
Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged / physiology*
Alzheimer Disease / drug therapy*,  economics,  physiopathology
Cholinesterase Inhibitors / economics,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Reg. No./Substance:
0/Cholinesterase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear mag...
Next Document:  Pharmacological management of renal colic in the older patient.