Document Detail

A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia.
MedLine Citation:
PMID:  12164565     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of long-term transdermal administration (range, 4-30 days; mean +/- SD, 11.1+/-7.2 days) of isosorbide dinitrate, a nitric oxide donor, in preeclamptic women. METHODS: We studied uterine and fetoplacental circulation of 12 preeclamptic women with oligohydramnios and an elevated pulsatility index in the uterine arteries. RESULTS: Transdermal isosorbide dinitrate significantly suppressed the blood pressure of patients. Pulsed Doppler ultrasonography revealed that the average pulsatility index in the uterine arteries was significantly reduced by treatment with isosorbide dinitrate (P < .003). The average pulsatility index in the umbilical artery was also significantly reduced (P < .004). Furthermore, the size of the amniotic fluid pocket increased approximately 4-fold by treatment with isosorbide dinitrate. CONCLUSIONS: Long-term transdermal administration of isosorbide dinitrate improves fetoplacental circulation and may be effective therapy for avoiding maternal hypertension and oligohydramnios in some preeclamptic women.
Mikiya Nakatsuka; Masayo Takata; Katsuhiko Tada; Kazuo Asagiri; Toshihiro Habara; Soichi Noguchi; Takafumi Kudo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  21     ISSN:  0278-4297     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-07     Completed Date:  2003-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  831-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
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MeSH Terms
Administration, Cutaneous
Isosorbide Dinitrate / administration & dosage,  therapeutic use*
Nitric Oxide Donors / administration & dosage,  therapeutic use*
Placental Circulation / drug effects*
Pre-Eclampsia / drug therapy*,  physiopathology
Pulsatile Flow / drug effects
Time Factors
Reg. No./Substance:
0/Nitric Oxide Donors; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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