| The long-term suppression of ventricular arrhythmia by oral acebutolol in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 6778183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The short-term efficacy of oral acebutolol was evaluated in 20 patients with coronary artery disease and frequent premature ventricular contractions (PVCs) by serial 24-hour Holter monitoring before and while the patients were receiving an average daily dose of 1,100 mg. of acebutolol for four weeks. Fifty-five percent of the 20 patients showed a greater than 70% PVC reduction from baseline values. The only serious side effect during short-term therapy was mild, reversible cardiac decompensation in one patient. The long-term safety and continued efficacy of acebutolol was then evaluated over the next 11 months in nine of the 11 patients showing greater than 70% PVC reduction at four weeks. Two-thirds of these nine patients continued to show greater than 80% PVC reduction from baseline values at 12 months. One patient developed alopecia during long-term therapy. The majority of patients not responding well to acebutolol at four weeks had an actual increase in PVCs on acebutolol therapy. We conclude that acebutolol produces long-term, effective reduction in PVCs without serious toxicity in the majority of patients with ventricular ectopy. However, this drug appears to either produce an excellent response or no response with regard to PVC control in most instances. |
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Authors:
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N de Soyza; J J Kane; M L Murphy; A R Laddu; J E Doherty; J K Bissett |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 100 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-02-19 Completed Date: 1981-02-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 631-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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administration & dosage,
adverse effects,
therapeutic use* Administration, Oral Arrhythmias, Cardiac / complications, drug therapy* Blood Pressure / drug effects Coronary Disease / complications, drug therapy* Heart Rate / drug effects Humans Long-Term Care Male Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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37517-30-9/Acebutolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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