Document Detail


A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats.
MedLine Citation:
PMID:  18090539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The present study aimed to show whether long-term moderate magnesium (Mg)-deficient (150 mg/kg) and Mg-supplemented (3200 mg/kg) diets (versus control diet: 800 mg/kg), modified the occurrence of cardiovascular risk induced by aging in the rat. METHODS: Cardiovascular and arterial functions were determined by a systemic hemodynamic study and by ex vivo measurements of vasoconstriction and endothelium dependent-vasorelaxation. Arterial wall structure was determined using pressure myograph chamber and histomorphometric methods. RESULTS: The main changes observed in old rats (96 weeks old) fed a control diet, in comparison to adult rats (16 weeks old) were increased pulse pressure, a loss of aortic endothelium-dependent relaxation, increased aortic wall thickness and a decrease of the aortic wall elastin/collagen ratio. Long-term moderate Mg deficiency progressively increased systolic blood pressure. Intra-arterial pulse pressure was higher in Mg-deficient old rats than in age-matched control rats. Histological examination showed that Mg deficiency increased the age-induced deleterious effects on composition and structure of aorta (media thickness, increased collagen content and reduction in the elastin/collagen ratio), which lead to large artery rigidity. Hypertension and increased pulse pressure may have contributed to the increase in the mortality rate observed in the hypertensive Mg-deficient group. Although the long-term Mg-supplemented diet lowered blood pressure and decreased the mortality rate, it had no significant effect on aortic wall thickening and stiffening. CONCLUSION: It is suggested that a long-term and moderate Mg-deficient diet increases age-induced arterial thickness and stiffness in rats, and thus increases the cardiovascular risks incurred by aging.
Authors:
Marcus Adrian; Evelyne Chanut; Pascal Laurant; Vincent Gaume; Alain Berthelot
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  26     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Affiliation:
EA3921 Metabolic and cellular optimisation, Université de Franche-Comté, UFR Sciences Médicales et Pharmaceutiques, Besançon, France.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Aging* / pathology
Animals
Aorta / drug effects,  pathology,  physiopathology*
Blood Pressure / drug effects
Cardiovascular Diseases / etiology,  pathology,  physiopathology*
Dietary Supplements
Endothelin-1 / pharmacology
Food, Formulated*
Magnesium / administration & dosage*,  blood
Magnesium Deficiency / complications,  physiopathology*,  prevention & control
Male
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Organ Culture Techniques
Rats
Rats, Sprague-Dawley
Risk Factors
Survival Rate
Time
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Vasomotor System / drug effects
Chemical
Reg. No./Substance:
0/Endothelin-1; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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