| A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats. | |
| | |
MedLine Citation:
|
PMID: 18090539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The present study aimed to show whether long-term moderate magnesium (Mg)-deficient (150 mg/kg) and Mg-supplemented (3200 mg/kg) diets (versus control diet: 800 mg/kg), modified the occurrence of cardiovascular risk induced by aging in the rat. METHODS: Cardiovascular and arterial functions were determined by a systemic hemodynamic study and by ex vivo measurements of vasoconstriction and endothelium dependent-vasorelaxation. Arterial wall structure was determined using pressure myograph chamber and histomorphometric methods. RESULTS: The main changes observed in old rats (96 weeks old) fed a control diet, in comparison to adult rats (16 weeks old) were increased pulse pressure, a loss of aortic endothelium-dependent relaxation, increased aortic wall thickness and a decrease of the aortic wall elastin/collagen ratio. Long-term moderate Mg deficiency progressively increased systolic blood pressure. Intra-arterial pulse pressure was higher in Mg-deficient old rats than in age-matched control rats. Histological examination showed that Mg deficiency increased the age-induced deleterious effects on composition and structure of aorta (media thickness, increased collagen content and reduction in the elastin/collagen ratio), which lead to large artery rigidity. Hypertension and increased pulse pressure may have contributed to the increase in the mortality rate observed in the hypertensive Mg-deficient group. Although the long-term Mg-supplemented diet lowered blood pressure and decreased the mortality rate, it had no significant effect on aortic wall thickening and stiffening. CONCLUSION: It is suggested that a long-term and moderate Mg-deficient diet increases age-induced arterial thickness and stiffness in rats, and thus increases the cardiovascular risks incurred by aging. |
| | |
Authors:
|
Marcus Adrian; Evelyne Chanut; Pascal Laurant; Vincent Gaume; Alain Berthelot |
Related Documents
:
|
3999759 - Computer analysis of intraarterially recorded blood pressure in conscious unrestrained ... 7613529 - Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats. 7104849 - A hypertensive substance in erythrocytes of spontaneously hypertensive rats. 4045189 - Redevelopment of elevated blood pressure following adrenalectomy in rats with isolation... 22466809 - Pressure effects on the magnetic behaviour of copper (ii) compounds: magnetic ordering ... 3820409 - Chronic digitalis administration alters mesenteric vascular reactivity. 3350679 - Use of fiber-optic pressure transducer for intracranial pressure measurements: a prelim... 2599669 - Are changes in intracranial pressure during intermittent machine haemofiltration depend... 18544809 - Stroke volume estimation in heart failure patients using bioimpedance: a realistic simu... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of hypertension Volume: 26 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2007-12-19 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 44-52 Citation Subset: IM |
Affiliation:
|
EA3921 Metabolic and cellular optimisation, Université de Franche-Comté, UFR Sciences Médicales et Pharmaceutiques, Besançon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology Aging* / pathology Animals Aorta / drug effects, pathology, physiopathology* Blood Pressure / drug effects Cardiovascular Diseases / etiology, pathology, physiopathology* Dietary Supplements Endothelin-1 / pharmacology Food, Formulated* Magnesium / administration & dosage*, blood Magnesium Deficiency / complications, physiopathology*, prevention & control Male Nitroprusside / pharmacology Norepinephrine / pharmacology Organ Culture Techniques Rats Rats, Sprague-Dawley Risk Factors Survival Rate Time Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology Vasomotor System / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Endothelin-1; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Automatic blood pressure measurement: the oscillometric waveform shape is a potential contributor to...
Next Document: Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep.