Document Detail

The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage.
MedLine Citation:
PMID:  20705479     Owner:  NLM     Status:  MEDLINE    
Experimental salmon thrombin/fibrinogen dressings have been shown to provide effective hemostasis in severe hemorrhage situations. The hypothesis for this study was that swine would still remain healthy without coagulopathy six months after exposure to salmon thrombin/fibrinogen dressings. Initial exposure was by insertion of the salmon dressing into the peritoneal cavity. Three months after the initial exposure, the same animals were subjected to two full thickness dermal wounds on the dorsal surface. One wound was bandaged with the salmon thrombin/fibrinogen bandage and the other wound was dressed with a standard bandage. The animals were monitored for an additional three months. Blood was drawn every 14 days over the six months for immunological and coagulation function analysis. All of the animals (8 pigs) remained healthy during the six month period and the dermal wounds healed without incidence. Lymph nodes and spleen showed signs of normal immune response and Western blots showed development of antibodies against salmon fibrinogen, but none of the animals made antibodies that recognized any species of thrombin. Coagulation parameters (fibrinogen concentration, thrombin time, PT and aPTT) and hematological parameters remained normal over the course of the study when compared to initial values of the subject swine.
Stephen W Rothwell; Timothy Settle; Shannon Wallace; Jennifer Dorsey; David Simpson; James R Bowman; Paul Janmey; Evelyn Sawyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-11
Journal Detail:
Title:  Biologicals : journal of the International Association of Biological Standardization     Volume:  38     ISSN:  1095-8320     ISO Abbreviation:  Biologicals     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2011-03-10     Revised Date:  2014-02-27    
Medline Journal Info:
Nlm Unique ID:  9004494     Medline TA:  Biologicals     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-28     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Fibrinogen / administration & dosage,  immunology*
Thrombin / administration & dosage,  immunology*
Wound Healing
Grant Support
Reg. No./Substance:
9001-32-5/Fibrinogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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