| A long-term follow-up of zonisamide monotherapy. | |
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MedLine Citation:
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PMID: 17116025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Several studies have reported the safety and efficacy of zonisamide monotherapy, but studies on its long-term outcomes are limited. This chart review was conducted to evaluate the long-term outcomes of zonisamide monotherapy. METHODS: The charts were reviewed for 77 patients treated with zonisamide as monotherapy for 6-180 months between May 1985 and December 2003. Outcomes were analyzed by the following subcategories: patients with newly diagnosed epilepsy or with antiepileptic drug-resistant epilepsy, the type of epilepsy, patient age, and treatment period. RESULTS: Of a total of 77 patients, 49 patients (64%) attained 50% or more reduction of seizure frequency and of those patients 38 (49%) attained 75% or more reduction, with 18 patients (24%) becoming seizure-free from 6 to 180 (median 80.6 +/- 43.6) months of follow-up. Thirty-eight patients (49%) continued zonisamide monotherapy as of December 2003. Proportions of patients having 75% or more reduction in seizure frequency in subcategories were as follows; 56% in patients with newly diagnosed epilepsy and 48% in patients whose treatment was switched to zonisamide monotherapy owing to lack of efficacy of or adverse reaction to previous antiepileptic drugs; 60% in patients with localization-related epilepsies and 38% in patients with generalized epilepsies; and 49% in pediatric patients and 50% in adult patients. CONCLUSION: Long-term zonisamide monotherapy was efficacious in a wide range of patients with epilepsy. Zonisamide did not seem to exhibit a reduction in efficacy during long-term use of up to 180 months. |
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Authors:
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Katsuyuki Fukushima; Masakazu Seino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 47 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 1860-4 Citation Subset: IM |
Affiliation:
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National Epilepsy Center, Shizuoka Medical Institute of Neurological Disorders, Shizuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Anticonvulsants / therapeutic use* Child Epilepsy / drug therapy* Female Follow-Up Studies Humans Isoxazoles / therapeutic use* Longitudinal Studies Male Medical Records Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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