Document Detail

A long-term follow-up study in essential cryoglobulinemia.
MedLine Citation:
PMID:  105549     Owner:  NLM     Status:  MEDLINE    
In a case series of 56 patients with essential cryoglobulinemia, 35 were followed-up for 4-13 years (mean 7 years). A membranous proliferative glomerulonephritis, which in about half the cases showed a progression to renal insufficiency, was the commonest complication, observed in more than one third of the patients. In 2 patients hepatic cirrhosis became manifest after a completely asymptomatic period and in 2 others a lymphoproliferative disease appeared 2 and 8 years after the onset of purpura. In 51% of patients the intial clinical pattern did not change. In searching for a correlation between the development of nephropathy and cryoglobulin characteristics, none was demonstrated studying the cryoglobulin level, the presence of autoantibody and the complement components.
F Invernizzi; P Pioltelli; R Cattaneo; V Gavazzeni; P Borzini; G Monti; C Zanussi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  61     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1979  
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  93-9     Citation Subset:  IM    
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MeSH Terms
Antibodies / analysis
Autoantibodies / analysis
Complement System Proteins / analysis
Cryoglobulins* / analysis
DNA / immunology
Follow-Up Studies
Glomerulonephritis / etiology
Kidney Failure, Chronic / etiology
Liver Cirrhosis / etiology
Lymphoproliferative Disorders / etiology
Middle Aged
Paraproteinemias / blood,  complications*,  immunology
Waldenstrom Macroglobulinemia / etiology
Reg. No./Substance:
0/Antibodies; 0/Autoantibodies; 0/Cryoglobulins; 9007-36-7/Complement System Proteins; 9007-49-2/DNA

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