Document Detail

The long-term effect of a calcium diet on the bone tissue, C-cells and parathyroid glands of the rat.
MedLine Citation:
PMID:  8282964     Owner:  NLM     Status:  MEDLINE    
In this experiment of 11 month-duration, 18 female Wistar rats received controlled amounts of calcium with food and water, to produce a state of either hypocalcemia or hypercalcemia. After a long-term low calcium diet hypocalcemia disappeared. This group of animals showed insignificant increases in the nuclear-cytoplasmic ratio of the parathyroid cells as well as in the total volume of the parathyroid glands, and a significant increase in the volume density of the osteoid. In the group receiving a high calcium diet, hypercalcemia was still present after 11 month. The insignificantly smaller and more numerous C-cells produced more calcitonin than normally. The parathyroid cells were significantly smaller and the numerical areal density of the osteoclasts was significantly lower than in the control group. It can be concluded that the parathyroid glands and C-cells are involved in the maintenance of blood calcium homeostasis during a long-term experiment on rats receiving low or high calcium diet.
M Logonder-Mlinsek; Z Pajer
Related Documents :
21736774 - Tannic acid is more effective than clofibrate for the elevation of hepatic β-oxidation ...
1944754 - Enhancement of ionized calcium and 1,25-dihydroxycholecalciferol loss from peritoneal f...
17030114 - Effect of calcium fortified milk supplementation with or without vitamin k on biochemic...
16733494 - Two stage edta anti-calcification method for bioprosthetic heart valve materials.
1769214 - Milk composition in an american marsupial (monodelphis domestica).
16582584 - The antiatherogenic effect of allicin: possible mode of action.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  16     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  687-90     Citation Subset:  IM    
Institute of Histology and Embryology, Medical Faculty, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Density / drug effects*
Calcitonin / blood*
Calcium / blood*
Calcium, Dietary / administration & dosage*,  pharmacology
Hypercalcemia / blood*,  etiology,  pathology
Hypocalcemia / blood*,  etiology,  pathology
Parathyroid Glands / drug effects,  pathology*
Parathyroid Hormone / blood
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Calcium, Dietary; 0/Parathyroid Hormone; 7440-70-2/Calcium; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Computer assisted sperm motility analysis at the moment of induced pregnancy during gonadotropin tre...
Next Document:  Insulin-like growth factor I values in patients on maintenance hemodialysis: relationship to growth ...