Document Detail

The long-term course of spike and wave complexes in the waking EEG of chronic schizophrenics.
MedLine Citation:
PMID:  9465284     Owner:  NLM     Status:  MEDLINE    
Nineteen chronic schizophrenics (8 males and 11 females) showed at least one spike and wave complex (SpW) in their rested-awake EEGs during long-term neuroleptic treatment. The age at the first appearance of the SpW ranged from 16 to 60 years, and the duration of neuroleptic medication preceding its appearance was from 1 to 35 years. Two types of SpW waveform were discriminated; one was a diffuse high voltage isolated 3.5-4 Hz SpW complex, and the other a diffuse moderate voltage 5-6 Hz SpW burst. In EEG studies repeated over the long-term, the presence of SpW was transient in 11 cases, intermittent in 5 cases, and continuous in 3 cases. Three patients had generalized tonic-clonic clinical seizures; two of their EEGs did not show SpW until after the onset of seizures. All three responded well to adjunctive anticonvulsant therapy. The other 16 patients exhibited SpW but did not have clinical seizures with or without prophylactic use of anticonvulsants. The SpW in the EEG of chronic schizophrenics might be an indicator of predisposition for seizure, but it is not a good predictor of seizure.
M Matsuura; M Yoshino; H Onda; T Kojima
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical EEG (electroencephalography)     Volume:  27     ISSN:  0009-9155     ISO Abbreviation:  Clin Electroencephalogr     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1998-02-25     Completed Date:  1998-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236454     Medline TA:  Clin Electroencephalogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-9     Citation Subset:  IM    
Department of Neuropsychiatry, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Longitudinal Studies
Middle Aged
Retrospective Studies
Schizophrenia / drug therapy,  physiopathology*
Reg. No./Substance:
0/Antipsychotic Agents

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