Document Detail

The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
MedLine Citation:
PMID:  9813238     Owner:  NLM     Status:  MEDLINE    
Both intracerebroventricular (i.c.v.) IL-1beta and exposure to inescapable tail shock (IS) activate acute phase responses (APRs) that include increases in core body temperature (CBT), increases in hypothalamic-pituitary-adrenal activity, decreases in carrier proteins such as corticosterone binding globulin (CBG), aphagia and adipsia. A variety of data suggested that stressors produce APRs by inducing brain IL-1beta. The current series of studies further explored this possibility by determining whether the functional IL-1beta antagonist, alpha-melanocyte-stimulating hormone (alpha-MSH(1-13)), would block IS-induced APRs. Immediately following i.c.v. alpha-MSH(1-13) administration, rats were exposed to a single session of 100, 5 s, 1.6 mA ISs, or control treatment (home cage control). alpha-MSH(1-13) blocked IS-induced increased CBT, increased plasma corticosterone (CORT), decreased CBG, aphagia and adipsia 24 h after IS. The inhibitory effects of alpha-MSH(1-13) were shown not to be a consequence of alpha-MSH(1-13) producing its actions 24 h after its administration because alpha-MSH(1-13) given 24 h before IS did not block IS-induced increased CBT and CORT during IS. Additionally, alpha-MSH(1-13), given 24 h before IS, had no effect on increased CBT, increased CORT, decreased CBG, adipsia, or aphagia 24 h after IS. These data provide support for a specific mode of action for i.c.v. alpha-MSH(1-13), namely blockade of APRs with no impact on acute hyperthermia or increased levels of CORT produced during IS.
E D Milligan; K T Nguyen; T Deak; J L Hinde; M Fleshner; L R Watkins; S F Maier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  810     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  48-58     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Elsevier Science B.V.
Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309-0345, USA.
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MeSH Terms
Acute-Phase Reaction / physiopathology,  prevention & control*,  psychology
Body Temperature / physiology
Drinking / physiology
Eating / physiology
Hydrocortisone / blood
Injections, Intraventricular
Rats, Sprague-Dawley
Stress, Psychological / complications*
alpha-MSH / administration & dosage,  pharmacology*
Grant Support
Reg. No./Substance:
50-23-7/Hydrocortisone; 581-05-5/alpha-MSH

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