Document Detail

The long and short of it: somite formation in mice.
MedLine Citation:
PMID:  16724326     Owner:  NLM     Status:  MEDLINE    
A fundamental characteristic of the vertebrate body plan is its segmentation along the anterior-posterior axis. This segmental pattern is established during embryogenesis by the formation of somites, the transient epithelial blocks of cells that derive from the unsegmented presomitic mesoderm. Somite formation involves a molecular oscillator, termed the segmentation clock, in combination with gradients of signaling molecules such as fibroblast growth factor 8, WNT3A, and retinoic acid. Disruption of somitogenesis in humans can result in disorders such as spondylocostal dysostosis, which is characterized by vertebral malformations. This review summarizes recent findings concerning the role of Notch signaling in the segmentation clock, the complex regulatory network that governs somitogenesis, the genes that cause inherited spondylocostal dysostosis, and the mechanisms that regulate bilaterally symmetric somite formation.
Thomas Gridley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  235     ISSN:  1058-8388     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2006-11-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2330-6     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
The Jackson Laboratory, Bar Harbor, Maine, USA.
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MeSH Terms
Biological Clocks
Body Patterning
Gene Expression Regulation, Developmental
Genes, Homeobox
Mesoderm / cytology,  metabolism
Receptors, Notch / genetics,  metabolism
Signal Transduction
Somites / cytology*,  metabolism
Spine / abnormalities,  embryology
Grant Support
Reg. No./Substance:
0/Receptors, Notch

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