Document Detail


The long-acting somatostatin analogue octreotide decreases pancreatic islet blood flow in rats.
MedLine Citation:
PMID:  8022759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intravenously administered octreotide (5 or 10 micrograms/kg body weight) on pyloric, duodenal, colonic, pancreatic, and islet blood flow were investigated with a microsphere technique in anesthetized rats. The lower dose of octreotide reduced only pyloric blood flow, while the higher dose caused a reduction also in duodenal and colonic blood flow. Whole pancreatic blood flow was not affected by either of the doses of octreotide, but the blood flow through the islets was decreased by the higher dose. Also, the fraction of whole pancreatic blood flow through the islets was decreased by the higher dose. It is concluded that octreotide mainly affects intestinal blood flow, but not whole pancreatic blood flow in rats. However, octreotide causes a redistribution of the blood flow within the pancreas, which leads to a diminished islet blood perfusion, in conjunction with a decrease in serum insulin concentration.
Authors:
P O Carlsson; L Jansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  9     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-08-04     Completed Date:  1994-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Biology, Uppsala University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Islets of Langerhans / blood supply,  drug effects*
Male
Octreotide / pharmacology*
Rats
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
83150-76-9/Octreotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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