| The long-acting somatostatin analogue octreotide decreases pancreatic islet blood flow in rats. | |
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MedLine Citation:
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PMID: 8022759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of intravenously administered octreotide (5 or 10 micrograms/kg body weight) on pyloric, duodenal, colonic, pancreatic, and islet blood flow were investigated with a microsphere technique in anesthetized rats. The lower dose of octreotide reduced only pyloric blood flow, while the higher dose caused a reduction also in duodenal and colonic blood flow. Whole pancreatic blood flow was not affected by either of the doses of octreotide, but the blood flow through the islets was decreased by the higher dose. Also, the fraction of whole pancreatic blood flow through the islets was decreased by the higher dose. It is concluded that octreotide mainly affects intestinal blood flow, but not whole pancreatic blood flow in rats. However, octreotide causes a redistribution of the blood flow within the pancreas, which leads to a diminished islet blood perfusion, in conjunction with a decrease in serum insulin concentration. |
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Authors:
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P O Carlsson; L Jansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 9 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-08-04 Completed Date: 1994-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 361-4 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Islets of Langerhans / blood supply, drug effects* Male Octreotide / pharmacology* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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