| A long-acting repeatable form of bromocriptine as long-term treatment of prolactin-secreting macroadenomas: a multicenter study. | |
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MedLine Citation:
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PMID: 1730334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the efficacy and tolerability of monthly injections of the long-acting repeatable bromocriptine in patients with macroprolactinomas. DESIGN: Open and prospective trial. SETTING: This multicenter trial was carried out in seven university hospitals. PATIENTS: Forty-two patients with prolactin (PRL)-secreting macroadenomas. INTERVENTIONS: Fifty to 200 mg of the drug were administered intragluteally every 28 days for 6 to 24 months. MAIN OUTCOME MEASURES: The efficacy was assessed by repetitive plasma PRL measurements, visual field determinations, and computed tomography scan examinations. RESULTS: After the first 50-mg injection, the mean percentage decrease of PRL levels was 71% from baseline on day 14; between days 1 and 28, PRL levels were suppressed to normal in nine cases, and a clear tumor shrinkage was documented in 21% of the patients. Normalization of PRL secretion was obtained in 62%, and a clear-cut reduction in tumor size in 50% of the patients after 6 months of treatment. CONCLUSIONS: The long-acting repeatable form of bromocriptine was a well tolerated and quickly effective treatment in most of these patients with macroprolactinomas. |
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Authors:
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T Brue; I Lancranjan; J P Louvet; D Dewailly; P Roger; P Jaquet |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fertility and sterility Volume: 57 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-02-18 Completed Date: 1992-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 74-80 Citation Subset: IM |
Affiliation:
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Centre Hospitalier Universitaire Nord, Marseille, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
drug therapy*,
secretion,
surgery Adult Bromocriptine / administration & dosage, therapeutic use* Delayed-Action Preparations Drug Administration Schedule Female Follow-Up Studies Galactorrhea / drug therapy, etiology Humans Infertility, Female / etiology Injections, Intramuscular Menstrual Cycle Microspheres Pituitary Neoplasms / drug therapy*, secretion, surgery Prolactin / blood, secretion* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 25614-03-3/Bromocriptine; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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