Document Detail

The long-acting phosphodiesterase inhibitor tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia.
MedLine Citation:
PMID:  17614028     Owner:  NLM     Status:  MEDLINE    
Whereas experimental studies showed that in healthy trained subjects, the phosphodiesterase-5 inhibitor (PDE-5i) sildenafil improves exercise capacity in hypoxia and not in normoxia, no studies on the effects of the long half-life PDE-5i tadalafil exist. In order to evaluate whether tadalafil influences functional parameters and performance during a maximal exercise test in normoxia, we studied 14 healthy male athletes in a double-blind cross-over protocol. Each athlete performed two tests on a cycle ergometer, both after placebo or tadalafil (at therapeutic dose: 20 mg) administration. Oxygen consumption (VO2), blood lactate, respiratory exchange ratio, rate of perceived exertion, arterial blood pressure (BP), heart frequency (HR) and oxygen pulse (VO2/HR) were evaluated before exercise, at individual ventilatory and anaerobic thresholds (IVT and IAT), at VO2max and during recovery. Compared to placebo, a single tadalafil administration significantly reduced systolic BP before and after exercise (p < 0.05), decreased VO2/HR at IVT (13.3 +/- 1.8 vs. 14.5 +/- 2.1 mL . beat (-1); p = 0.03), but did not modify individual VO2max, IVT, or IAT. In healthy athletes, 20 mg of tadalafil does not substantially influence physical fitness-related parameters, exercise tolerance, and cardiopulmonary responses to maximal exercise in normoxia; it remains to be verified if higher doses/prolonged use influence health and/or sport performance in field conditions.
L Di Luigi; C Baldari; F Pigozzi; G P Emerenziani; M C Gallotta; F Iellamo; E Ciminelli; P Sgrò; F Romanelli; A Lenzi; L Guidetti
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Publication Detail:
Type:  Journal Article     Date:  2007-07-05
Journal Detail:
Title:  International journal of sports medicine     Volume:  29     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  110-5     Citation Subset:  IM    
Department of Health Sciences, University of Rome IUSM, Rome, Italy.
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MeSH Terms
Anaerobic Threshold / drug effects*
Carbolines / administration & dosage,  pharmacology*
Cross-Over Studies
Delayed-Action Preparations / pharmacology*
Double-Blind Method
Exercise Test / methods
Oxygen Consumption / drug effects*,  physiology
Phosphodiesterase Inhibitors / administration & dosage,  pharmacology*
Physical Endurance
Placebos / administration & dosage,  pharmacology
Reg. No./Substance:
0/Carbolines; 0/Delayed-Action Preparations; 0/Phosphodiesterase Inhibitors; 0/Placebos; 0/tadalafil

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