Document Detail


On the logic of restrictive recognition of peptide by the T-cell antigen receptor.
MedLine Citation:
PMID:  20931295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This essay provides an analysis of the inadequacy of the current view of restrictive recognition of peptide by the T-cell antigen receptor. A competing model is developed, and the experimental evidence for the prevailing model is reinterpreted in the new framework. The goal is to contrast the two models with respect to their consistency, coverage of the data, explanatory power, and predictability.
Authors:
Melvin Cohn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Immunologic research     Volume:  50     ISSN:  1559-0755     ISO Abbreviation:  Immunol. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-68     Citation Subset:  IM    
Affiliation:
Conceptual Immunology Group, The Salk Institute For Biological Studies, La Jolla, CA 92037, USA. cohn@salk.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Models, Immunological
Peptides / immunology*
Receptors, Antigen, T-Cell / immunology*
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
R01 RR007716-21/RR/NCRR NIH HHS; RR07716/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Peptides; 0/Receptors, Antigen, T-Cell
Comments/Corrections

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