| The logic of causation and the risk of paralytic poliomyelitis for an American child. | |
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MedLine Citation:
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PMID: 10722138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beginning in January 1997, American immunization policy allowed parents and physicians to elect one of three approved infant vaccination strategies for preventing poliomyelitis. Although the three strategies likely have different outcomes with respect to prevention of paralytic poliomyelitis, the extreme rarity of the disease in the USA prevents any controlled comparison. In this paper, a formal inferential logic, originally described by Donald Rubin, is applied to the vaccination problem. Assumptions and indirect evidence are used to overcome the inability to observe the same subjects under varying conditions to allow the inference of causality from non-randomized observations. Using available epidemiologic information and explicit assumptions, it is possible to project the risk of paralytic polio for infants immunized with oral polio vaccine (1.3 cases per million vaccinees), inactivated polio vaccine (0.54 cases per million vaccinees), or a sequential schedule (0.54-0.92 cases per million vaccinees). |
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Authors:
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D Ridgway |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epidemiology and infection Volume: 124 ISSN: 0950-2688 ISO Abbreviation: Epidemiol. Infect. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-29 Completed Date: 2000-03-29 Revised Date: 2010-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8703737 Medline TA: Epidemiol Infect Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Affiliation:
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Lineberry Research Associates, Research Triangle Park, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Causality Child Child, Preschool Humans Immunization Programs* Infant Injections Models, Theoretical Poliomyelitis / chemically induced, epidemiology, prevention & control* Poliovirus Vaccine, Inactivated / administration & dosage*, adverse effects Poliovirus Vaccine, Oral / administration & dosage, adverse effects Risk Assessment / methods United States / epidemiology Vaccines, Inactivated / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Poliovirus Vaccine, Inactivated; 0/Poliovirus Vaccine, Oral; 0/Vaccines, Inactivated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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