Document Detail


The locus of flicker adaptation in the migraine visual system: a dichoptic study.
MedLine Citation:
PMID:  23147164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Flickering light has been shown to sensitize the migraine visual system at high stimulus contrast while elevating thresholds at low contrast. The present study employs a dichoptic psychophysical paradigm to ask whether the abnormal adaptation to flicker in migraine occurs before or after the binocular combination of inputs from the two eyes in the visual cortex.
METHODS: Following adaptation to high contrast flicker presented to one eye only, flicker contrast increment thresholds were measured in each eye separately using dichoptic viewing.
RESULTS: Modest interocular transfer of adaptation was seen in both migraine and control groups at low contrast. Sensitization at high contrast in migraine relative to control participants was seen in the adapted eye only, and an unanticipated threshold elevation occurred in the non-adapted eye. Migraineurs also showed significantly lower aversion thresholds to full field flicker than control participants, but aversion scores and increment thresholds were not correlated.
CONCLUSIONS: The results are simulated with a three-stage neural model of adaptation that points to strong adaptation at monocular sites prior to binocular combination, and weaker adaptation at the level of cortical binocular neurons. The sensitization at high contrast in migraine is proposed to result from stronger adaptation of inhibitory neurons, which act as a monocular normalization pool.
Authors:
Michel Thabet; Frances Wilkinson; Hugh R Wilson; Olivera Karanovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-12
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  33     ISSN:  1468-2982     ISO Abbreviation:  Cephalalgia     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-07-25     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Female
Humans
Light
Male
Migraine Disorders / physiopathology*
Photic Stimulation
Sensory Thresholds / physiology
Visual Perception / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
94417-1//Canadian Institutes of Health Research; IGO-94417//Canadian Institutes of Health Research
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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