Document Detail

The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color.
MedLine Citation:
PMID:  18627529     Owner:  NLM     Status:  MEDLINE    
Melanocytes are mainly found in the skin and more rarely in other parts of the body, including the heart. We analyzed the localization of heart melanocytes and their levels of pigmentation in a series of mutant mice presenting different numbers of melanocytes and pigmentation in the skin. We found that melanocytes were localized in the valves (mitral, tricuspid, and aortic) and septa (ventricular and atrial). Moreover, the numbers of melanocytes in the heart appears to reflect that of the skin. Mice having a high or low level of pigmented cells and/or melanin in valves and septa have similar lifespan. In this respect, melanocytes found in the valves and septa of the heart are probably not essential in a healthy and non-stressful environment.
Ichiro Yajima; Lionel Larue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-27
Journal Detail:
Title:  Pigment cell & melanoma research     Volume:  21     ISSN:  1755-1471     ISO Abbreviation:  Pigment Cell Melanoma Res     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-10-20     Revised Date:  2009-12-11    
Medline Journal Info:
Nlm Unique ID:  101318927     Medline TA:  Pigment Cell Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  IM    
Developmental Genetics of Melanocytes, UMR 146 CNRS, Institut Curie, Orsay Cedex, France.
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MeSH Terms
Hair / physiology*
Lac Operon
Melanocytes / cytology*
Mice, Inbred C57BL
Mice, Transgenic
Microphthalmia-Associated Transcription Factor / genetics
Myocardium / cytology*
Pigmentation / genetics,  physiology*
Reg. No./Substance:
0/Microphthalmia-Associated Transcription Factor; 0/Mitf protein, mouse

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