| The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color. | |
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MedLine Citation:
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PMID: 18627529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melanocytes are mainly found in the skin and more rarely in other parts of the body, including the heart. We analyzed the localization of heart melanocytes and their levels of pigmentation in a series of mutant mice presenting different numbers of melanocytes and pigmentation in the skin. We found that melanocytes were localized in the valves (mitral, tricuspid, and aortic) and septa (ventricular and atrial). Moreover, the numbers of melanocytes in the heart appears to reflect that of the skin. Mice having a high or low level of pigmented cells and/or melanin in valves and septa have similar lifespan. In this respect, melanocytes found in the valves and septa of the heart are probably not essential in a healthy and non-stressful environment. |
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Authors:
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Ichiro Yajima; Lionel Larue |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-27 |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: 21 ISSN: 1755-1471 ISO Abbreviation: Pigment Cell Melanoma Res Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-19 Completed Date: 2008-10-20 Revised Date: 2009-12-11 |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 471-6 Citation Subset: IM |
Affiliation:
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Developmental Genetics of Melanocytes, UMR 146 CNRS, Institut Curie, Orsay Cedex, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Color* Hair / physiology* Lac Operon Melanocytes / cytology* Mice Mice, Inbred C57BL Mice, Transgenic Microphthalmia-Associated Transcription Factor / genetics Myocardium / cytology* Pigmentation / genetics, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Microphthalmia-Associated Transcription Factor; 0/Mitf protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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