Document Detail


The localization of an inductive response.
MedLine Citation:
PMID:  2806117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combinations of tissues from Xenopus blastulae have been used to identify several mechanisms that limit the number of animal cells forming muscle after induction by vegetal cells. The results disagree with a model in which direct physical contact or very close proximity between animal and vegetal cells restricts the number of cells that receive the inductive signal. Rather it seems that a diffusible inducer is released by vegetal cells, and spreads through 4-8 animal cell diameters, equivalent to a distance of 80 microns, from the nearest vegetal cells. Several factors seem to cooperate to prevent the further spread of the mesoderm-forming induction. These include the slow diffusion and/or instability of the inducer, the time of loss of competence of animal cells to respond to induction, and the amount of vegetal tissue that releases inducer for a limited time. The combination of these, and perhaps other, processes seems to ensure that a consistent minority of animal cells are induced to form muscle, thereby leaving other animal cells available to form the nervous system and epidermis.
Authors:
J B Gurdon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  105     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-12-06     Completed Date:  1989-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
Embryonic Induction*
Mesoderm / physiology*
Muscles / embryology*
Xenopus laevis

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