Document Detail

The localization of focal heart activity via body surface potential measurements: tests in a heterogeneous torso phantom.
MedLine Citation:
PMID:  19700819     Owner:  NLM     Status:  MEDLINE    
The non-invasive localization of focal heart activity via body surface potential measurements (BSPM) could greatly benefit the understanding and treatment of arrhythmic heart diseases. However, the in vivo validation of source localization algorithms is rather difficult with currently available measurement techniques. In this study, we used a physical torso phantom composed of different conductive compartments and seven dipoles, which were placed in the anatomical position of the human heart in order to assess the performance of the Recursively Applied and Projected Multiple Signal Classification (RAP-MUSIC) algorithm. Electric potentials were measured on the torso surface for single dipoles with and without further uncorrelated or correlated dipole activity. The localization error averaged 11 +/- 5 mm over 22 dipoles, which shows the ability of RAP-MUSIC to distinguish an uncorrelated dipole from surrounding sources activity. For the first time, real computational modelling errors could be included within the validation procedure due to the physically modelled heterogeneities. In conclusion, the introduced heterogeneous torso phantom can be used to validate state-of-the-art algorithms under nearly realistic measurement conditions.
F Wetterling; M Liehr; P Schimpf; H Liu; J Haueisen
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-21
Journal Detail:
Title:  Physics in medicine and biology     Volume:  54     ISSN:  0031-9155     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-02     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  5395-409     Citation Subset:  IM    
Biomagnetic Center, Department of Neurology, Friedrich Schiller University Jena, Jena, Germany.
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MeSH Terms
Action Potentials / physiology*
Body Surface Potential Mapping / instrumentation*,  methods*
Equipment Design
Equipment Failure Analysis
Heart Conduction System / physiology*
Phantoms, Imaging
Reproducibility of Results
Sensitivity and Specificity

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