Document Detail

A loading dose/continuous infusion schedule of fludarabine phosphate in chronic lymphocytic leukemia.
MedLine Citation:
PMID:  1714949     Owner:  NLM     Status:  MEDLINE    
Using a loading dose/continuous infusion schedule, fludarabine phosphate was administered to 51 patients with previously treated chronic lymphocytic leukemia (CLL). All patients had evidence of active disease, and the majority had advanced Rai stages. Of the 42 patients assessable for response, 22 (52%) achieved a partial response, five (12%) had stable disease, and 15 (36%) progressed. Thirteen of the 22 responders improved their Rai stages with fludarabine therapy, including six patients who achieved stage 0. Response rates for pretreatment stages III and IV were 60% and 53%, respectively. Patients with final Rai stages 0 to II had better survival than those with stages III and IV. Patients who had undergone splenectomy before starting therapy were more likely to respond. Myelosuppression was the primary toxicity and did not appear to be cumulative. Severe leukopenia and thrombocytopenia, although infrequent, were associated with several deaths in the early cycles of treatment. Nonhematologic toxicity was mild with no serious neurotoxicity noted. Infections were common with 22 minor, 18 major, and 10 fatal episodes. Fludarabine phosphate by this alternative dosing schedule is effective in refractory advanced CLL and is well tolerated by the majority of patients.
C A Puccio; A Mittelman; S M Lichtman; R T Silver; D R Budman; T Ahmed; E J Feldman; M Coleman; P M Arnold; Z A Arlin
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  9     ISSN:  0732-183X     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-09-26     Completed Date:  1991-09-26     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1562-9     Citation Subset:  IM    
New York Medical College, Valhalla, 10595.
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MeSH Terms
Aged, 80 and over
Antimetabolites, Antineoplastic / administration & dosage*,  adverse effects
Combined Modality Therapy
Drug Administration Schedule
Drug Evaluation
Infusions, Intravenous
Injections, Intravenous
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*,  therapy
Middle Aged
Vidarabine Phosphate / administration & dosage,  adverse effects,  analogs & derivatives*
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 1X9VK9O1SC/fludarabine phosphate; 29984-33-6/Vidarabine Phosphate

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