Document Detail

A liquid concept--do classic preparations of body cavity fluid perform differently than ThinPrep cases? Observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.
MedLine Citation:
PMID:  18976004     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Newer liquid-based preparations differ morphologically from classic preparations (smears, filters, and cytocentrifuged preparations). Is adenocarcinoma more readily detected in liquid-based preparations? We reviewed responses from 16,750 fluid challenges of adenocarcinoma distributed in 2005 in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology (CAP NGC). OBJECTIVE: To compare the performance of body cavity fluid liquid-based preparations with adenocarcinoma to that in classic preparations in the CAP NGC. DESIGN: Responses for ThinPrep challenges were compared with classic preparations for exact match diagnoses of adenocarcinoma from pelvic washes, pleural fluid, pericardial fluid, and peritoneal fluids in the 2005 CAP NGC. RESULTS: A total of 13,690 pathologists, 8345 cytotechnologists, and 5958 laboratories submitted responses to fluid challenges in 2005. Adenocarcinoma comprised 16,750 of the fluid challenges; 88% were classic preparations, and 12% were ThinPrep challenges. The exact match to the reference diagnosis of adenocarcinoma was seen in 77% of conventional preparations and 81% of ThinPrep challenges when a general category of "positive for malignancy" was assigned. When "suspicious for malignancy," an exact match diagnosis of adenocarcinoma was made in 5% and 4% of classic and ThinPrep challenges, respectively. CONCLUSIONS: ThinPrep challenges performed slightly better overall, but only pelvic washings and peritoneal fluids demonstrated statistically significant improved performance with ThinPrep challenges. Use of liquid-based preparation is widespread for nongynecologic preparations and performs as well, and sometimes better than, classic preparations in an interlaboratory comparison program.
Ann T Moriarty; Mary R Schwartz; Barbara S Ducatman; Christine N Booth; Jennifer Haja; Subhendu Chakraborty; Beth Williamson;
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  132     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-03     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1716-8     Citation Subset:  AIM; IM    
AmeriPath Indiana, Indianapolis, IN 46219-1739, USA.
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MeSH Terms
Adenocarcinoma / diagnosis*,  pathology*
Body Fluids / cytology*
Pathology, Clinical / methods*
Retrospective Studies
Societies, Medical
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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