Document Detail


A liquid chromatography-tandem mass spectrometric method for quantification of curcumin-O-glucuronide and curcumin in human plasma.
MedLine Citation:
PMID:  22682887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Curcumin is a widely used herbal medicine for various human diseases including inflammation and cancer. The demonstration and optimization of curcumin's activities in the clinical setting, however, have been compromised by its poor bioavailability and the lack of analytic methods to monitor its absorption. In this paper, we report the first validated liquid chromatography-tandem mass spectrometric method for simultaneous quantification of curcumin and its major metabolite: curcumin-O-glucuronide (COG), in the linear range of 2.0-2000 ng/mL in human plasma. The intra-day and inter-day accuracies of curcumin and COG in human plasma were in the range of 91.3-111.5% and 82.7-109.2% and their co-efficiency of variations were in the range of 3.5-12.7% and 3.1-11.3%, respectively. This method was capable of detecting only COG in human plasma samples from two healthy volunteers after an oral ingestion of curcumin.
Authors:
Wei Chen; Patty Fan-Havard; Lisa D Yee; Yu Cao; Gary D Stoner; Kenneth K Chan; Zhongfa Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-26
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  900     ISSN:  1873-376X     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-10-19     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province 310022, China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Blood Chemical Analysis
Chromatography, Liquid / methods*
Curcumin / administration & dosage,  analysis*
Drug Stability
Glucuronides / blood*
Humans
Linear Models
Reproducibility of Results
Sensitivity and Specificity
Tandem Mass Spectrometry / methods*
Grant Support
ID/Acronym/Agency:
R21 CA135478/CA/NCI NIH HHS; R21 CA135478/CA/NCI NIH HHS; UL1 TR000090/TR/NCATS NIH HHS; UL1RR025755/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glucuronides; 458-37-7/Curcumin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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