Document Detail

The 12/15-lipoxygenase pathway promotes osteoclast development and differentiation.
MedLine Citation:
PMID:  19811308     Owner:  NLM     Status:  MEDLINE    
Although 12/15-lipoxygenase (12/15-LO) has been implicated as negative regulator of systemic bone mass in mice and humans, the underlying mechanisms remain elusive. Here, we show that 12/15-LO is a positive regulator of osteoclast (OC) development. Enzymatic inhibition as well as genetic ablation of 12/15-LO significantly impaired osteoclastogenesis. Conversely, addition of the 12/15-LO-derived eicosanoids 12- and 15-HETE augmented differentiation of precursors into fully matured OCs. Together these data point towards a crucial role of 12/15-LO in the regulation of OC development. Therefore, 12/15-LO and its human homologue 15-LO may display novel targets for the treatment of diseases such as osteoporosis and rheumatoid arthritis.
Gerhard Kr??nke; Stefan Uderhardt; Julia Katzenbeisser; Georg Schett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autoimmunity     Volume:  42     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  England    
Other Details:
Languages:  eng     Pagination:  383-5     Citation Subset:  IM    
Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054, Erlangen, Germany.
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MeSH Terms
Arachidonate 12-Lipoxygenase / metabolism*
Arachidonate 15-Lipoxygenase / metabolism*
Cell Differentiation / physiology*
Enzyme Inhibitors / pharmacology
Mice, Knockout
Osteoclasts / cytology*,  enzymology*
Signal Transduction / physiology*
Stem Cells / cytology,  drug effects
Reg. No./Substance:
0/Enzyme Inhibitors; EC 12-Lipoxygenase; EC 15-Lipoxygenase

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