| Is lipoprotein(a) regulating prostaglandin I2-synthesis stimulating plasma factor? | |
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MedLine Citation:
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PMID: 20229675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Lipoprotein(a) - Lp(a) is accepted as an independent risk factor for the development of atherosclerosis. The mechanism, however, and how it exerts its pathogenetic role is still unclear. More than a decade ago a deficiency of prostacyclin synthesis stimulating plasma factor (PF) was claimed to be associated with an increased Lp(a). OBJECTIVE: The aim of this retrospective analysis was to assess whether elevated Lp(a) is associated with a PF-deficiency and whether certain risk factors may exert influence. METHODS: In a total of 185 patients (131 men and 54 women), aged 30-85 years, suffering from clinically manifested atherosclerosis risk factor profile, lipids, lipoproteins and PF under drug intake were evaluated. RESULTS: Patients with absent PF-activity did not differ concerning age, height, weight, body mass index, waist circumference and different lipid and lipoprotein parameters. Mean Lp(a) in patients with absent PF-activity was 18 vs. 94 mg/dl (p < 0.001). Laboratory parameters such as C-reactive protein, fibrinogen, protein 5, protein C, activated protein C resistance and others were not different. In patients with normal (< 30 mg/dl) Lp(a) only 4 males (3.4%) and 3 females (4.8%) had PF-deficiency, while the Lp(a) cut-off of 30 mg/dl the prevalence was 61.1% males and 64.4.% females. CONCLUSION: These findings indicate that the association of PF-deficiency with increased Lp(a), at least in part, could contribute to the pathogenesis of atherosclerosis in these patients. |
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Authors:
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Helmut Sinzinger; Ernst Ruppert; Herbert Laimer |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Srpski arhiv za celokupno lekarstvo Volume: 138 Suppl 1 ISSN: 0370-8179 ISO Abbreviation: Srp Arh Celok Lek Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-16 Completed Date: 2010-04-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0027440 Medline TA: Srp Arh Celok Lek Country: Serbia |
Other Details:
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Languages: eng Pagination: 8-11 Citation Subset: IM |
Affiliation:
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Institute for Diagnosis and Treatment of Atherosclerosis and Lipid Disorders (ATHOS), Vienna, Austria. helmut.sinzinger@chello.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / metabolism Atherosclerosis / metabolism Biological Factors / physiology* Coronary Disease / metabolism* Epoprostenol / biosynthesis* Female Humans Lipoprotein(a) / physiology* Male Middle Aged Radioimmunoassay Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors; 0/Lipoprotein(a); 0/prostacyclin synthesis stimulating plasma factor; 35121-78-9/Epoprostenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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