| The lipid peroxidation products as possible markers of Alzheimer's disease in blood. | |
| | |
MedLine Citation:
|
PMID: 20920571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oxidative stress, which is present in Alzheimer's disease (AD), results in the formation of various end-products of free radical reactions with proteins and lipids. At present there are no reliable diagnostic biomarkers of AD in the blood. Therefore, specific products of lipid peroxidation in the blood of AD patients were investigated. Lipophilic extracts of erythrocytes in the group of patients with AD (n = 44) and age-matched controls (n = 16) were studied. The end-products of lipid peroxidation, so called lipofuscin-like pigments (LFP), were analysed by fluorescence spectroscopy. It was found that the level of these products is significantly increased in erythrocytes of AD patients compared to controls. LFP were further separated by means of HPLC into individual fractions to study their composition in AD and controls. The specific fraction of LFP in AD patients, which was isolated, might represent a disease-specific product in the blood. |
| | |
Authors:
|
A Skoumalová; J Ivica; P Santorová; E Topinková; J Wilhelm |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-12 |
Journal Detail:
|
Title: Experimental gerontology Volume: 46 ISSN: 1873-6815 ISO Abbreviation: Exp. Gerontol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-07 Completed Date: 2011-03-25 Revised Date: 2012-05-30 |
Medline Journal Info:
|
Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
|
Languages: eng Pagination: 38-42 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Medical Chemistry and Biochemistry, 2nd Faculty of Medicine Charles Universtity in Prague, Czech Republic. alice.skoumalova@lfmotol.cuni.cz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Alzheimer Disease / diagnosis*, metabolism* Biological Markers / metabolism* Chromatography, High Pressure Liquid Erythrocytes / metabolism* Female Humans Lipid Peroxidation / physiology* Lipofuscin / metabolism Male Oxidative Stress / physiology Spectrometry, Fluorescence |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Lipofuscin |
| Comments/Corrections | |
Erratum In:
|
Exp Gerontol. 2012 May;47(5):410 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) Cass.
Next Document: Protection in mice passively immunized with serum from cynomolgus macaques and humans vaccinated wit...