| The lipid messenger OEA links dietary fat intake to satiety. | |
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MedLine Citation:
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PMID: 18840358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The association between fat consumption and obesity underscores the need to identify physiological signals that control fat intake. Previous studies have shown that feeding stimulates small-intestinal mucosal cells to produce the lipid messenger oleoylethanolamide (OEA) which, when administered as a drug, decreases meal frequency by engaging peroxisome proliferator-activated receptors-alpha (PPAR-alpha). Here, we report that duodenal infusion of fat stimulates OEA mobilization in the proximal small intestine, whereas infusion of protein or carbohydrate does not. OEA production utilizes dietary oleic acid as a substrate and is disrupted in mutant mice lacking the membrane fatty-acid transporter CD36. Targeted disruption of CD36 or PPAR-alpha abrogates the satiety response induced by fat. The results suggest that activation of small-intestinal OEA mobilization, enabled by CD36-mediated uptake of dietary oleic acid, serves as a molecular sensor linking fat ingestion to satiety. |
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Authors:
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Gary J Schwartz; Jin Fu; Giuseppe Astarita; Xiaosong Li; Silvana Gaetani; Patrizia Campolongo; Vincenzo Cuomo; Daniele Piomelli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell metabolism Volume: 8 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2008-12-02 Revised Date: 2011-04-21 |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 281-8 Citation Subset: IM |
Affiliation:
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Diabetes Research Center, Departments of Medicine and Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD36 / metabolism Dietary Fats* Eating / drug effects* Epithelial Cells / cytology, drug effects*, metabolism Feeding Behavior / drug effects* Intestinal Mucosa / cytology*, metabolism Intestine, Small / anatomy & histology Lipid Metabolism Male Mice Mice, Knockout Oleic Acid / metabolism Oleic Acids / pharmacology* PPAR alpha / genetics, metabolism Rats Rats, Sprague-Dawley Rats, Wistar Satiation / physiology* Signal Transduction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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5P30DK026687/DK/NIDDK NIH HHS; DK047208/DK/NIDDK NIH HHS; DK073955/DK/NIDDK NIH HHS; P30 DK026687-269013/DK/NIDDK NIH HHS; R01 DK047208-11/DK/NIDDK NIH HHS; R01 DK047208-12/DK/NIDDK NIH HHS; R01 DK047208-13/DK/NIDDK NIH HHS; R01 DK047208-14/DK/NIDDK NIH HHS; R01 DK047208-15/DK/NIDDK NIH HHS; R01 DK047208-16/DK/NIDDK NIH HHS; R01 DK073955-01A2/DK/NIDDK NIH HHS; R01 DK073955-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD36; 0/Dietary Fats; 0/Oleic Acids; 0/PPAR alpha; 0/oleoylethanolamide; 112-80-1/Oleic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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