| The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans. | |
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MedLine Citation:
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PMID: 14699095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The coexistence of sexual and asexual reproductive cycles within the same individual is a striking phenomenon in numerous fungi. In the fungus Aspergillus nidulans (teleomorph: Emericella nidulans) endogenous oxylipins, called psi factor, serve as hormone-like signals that modulate the timing and balance between sexual and asexual spore development. Here, we report the identification of A. nidulans ppoA, encoding a putative fatty acid dioxygenase, involved in the biosynthesis of the linoleic acid derived oxylipin psiBalpha. PpoA is required for balancing anamorph and teleomorph development. Deletion of ppoA significantly reduced the level of psiBalpha and increased the ratio of asexual to sexual spore numbers 4-fold. In contrast, forced expression of ppoA resulted in elevated levels of psiBalpha and decreased the ratio of asexual to sexual spore numbers 6-fold. ppoA expression is mediated by two developmental regulators, VeA and the COP9 signalosome, such that ppoA transcript levels are correlated with the initiation of asexual and sexual fruiting body formation. PpoA localizes in lipid bodies in these tissues. These data support an important role for oxylipins in integrating mitotic and meiotic spore development. |
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Authors:
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Dimitrios I Tsitsigiannis; Robert Zarnowski; Nancy P Keller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2003-12-29 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 279 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-15 Completed Date: 2004-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 11344-53 Citation Subset: IM |
Affiliation:
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Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AY502073 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillus nidulans
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enzymology,
growth & development,
physiology* Base Sequence DNA Primers Fungal Proteins / physiology* Molecular Sequence Data Oxygenases / metabolism Peroxidases / metabolism Spores, Fungal* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Fungal Proteins; EC 1.11.1.-/Peroxidases; EC 1.13.-/Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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