Document Detail


The lipid body protein, PpoA, coordinates sexual and asexual sporulation in Aspergillus nidulans.
MedLine Citation:
PMID:  14699095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The coexistence of sexual and asexual reproductive cycles within the same individual is a striking phenomenon in numerous fungi. In the fungus Aspergillus nidulans (teleomorph: Emericella nidulans) endogenous oxylipins, called psi factor, serve as hormone-like signals that modulate the timing and balance between sexual and asexual spore development. Here, we report the identification of A. nidulans ppoA, encoding a putative fatty acid dioxygenase, involved in the biosynthesis of the linoleic acid derived oxylipin psiBalpha. PpoA is required for balancing anamorph and teleomorph development. Deletion of ppoA significantly reduced the level of psiBalpha and increased the ratio of asexual to sexual spore numbers 4-fold. In contrast, forced expression of ppoA resulted in elevated levels of psiBalpha and decreased the ratio of asexual to sexual spore numbers 6-fold. ppoA expression is mediated by two developmental regulators, VeA and the COP9 signalosome, such that ppoA transcript levels are correlated with the initiation of asexual and sexual fruiting body formation. PpoA localizes in lipid bodies in these tissues. These data support an important role for oxylipins in integrating mitotic and meiotic spore development.
Authors:
Dimitrios I Tsitsigiannis; Robert Zarnowski; Nancy P Keller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2003-12-29
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  279     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11344-53     Citation Subset:  IM    
Affiliation:
Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY502073
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MeSH Terms
Descriptor/Qualifier:
Aspergillus nidulans / enzymology,  growth & development,  physiology*
Base Sequence
DNA Primers
Fungal Proteins / physiology*
Molecular Sequence Data
Oxygenases / metabolism
Peroxidases / metabolism
Spores, Fungal*
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Fungal Proteins; EC 1.11.1.-/Peroxidases; EC 1.13.-/Oxygenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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