Document Detail

A linkage study of depression spectrum disease: the use of the sib-pair method.
MedLine Citation:
PMID:  794755     Owner:  NLM     Status:  MEDLINE    
Genetic linkage was studied in depression spectrum disease, a subgroup of unipolar depressive illness defined by presence of familial alcoholism and/or antisocial personality, using a version of the sib pair method of Penrose. Rigorous research diagnostic criteria were used and the diagnoses were made blind, i.e., without knowledge of the genetic marker results. Possibility of linkage was suggested (p less than 0.005) with the alpha-haptoglobin (alpha-Hp) and third complement component (C3) loci. However, the likelihood that these two markers are not on the same chromosome, and the limitations of the sib pair method, permit these findings to be treated as suggestive only and indicate that these two promising markers should be investigated further, using a more definitive method of linkage detection such as the lod score method.
V L Tanna; G Winokur; R C Elston; R C Go
Related Documents :
15342505 - High-density genetic linkage maps of phytophthora infestans reveal trisomic progeny and...
18538955 - Genome-wide linkage analysis of heroin dependence in han chinese: results from wave two...
9124705 - Chromosomal localization of six bovine microsatellite markers.
11793735 - Multipoint linkage analysis under heterogeneity: incorporation of parametric and nonpar...
10767325 - Single nucleotide polymorphism and linkage disequilibrium within the tcr alpha/delta lo...
11437065 - Epigenetic inheritance associated with human chromosome 14.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropsychobiology     Volume:  2     ISSN:  0302-282X     ISO Abbreviation:  Neuropsychobiology     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512895     Medline TA:  Neuropsychobiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  52-62     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcoholism / genetics
Depression / genetics*
Genetic Techniques
Linkage (Genetics)*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of photoperiod on gonadotropin releasing hormone-induced LH release in the immature rat.
Next Document:  Copper jacketed bullets in the central nervous system.