Document Detail

A linkage map of chromosome 6 based on 2 large kindreds segregating bipolar affective disorder.
MedLine Citation:
PMID:  10668958     Owner:  NLM     Status:  MEDLINE    
Twenty-eight markers, both simple sequence repeats (SSRs) and restriction fragment length polymorphisms (RFLPs), were genotyped on members of 2 large pedigrees (OOA, BIP167) segregating bipolar affective disorder. Using the multipoint program "build" of CRIMAP and odds of placement 1000:1, a unique sex-averaged map was generated that spans 227 cM and includes 26 markers. The two other markers were placed on the map with a lower likelihood. The female recombination map is larger than the male recombination map by about 80%. Linkage analysis between the polymorphisms and the disease in the OOA screening pedigree did not result in any significantly positive lod scores nor did a non-parametric, identity-by-descent, method generate any significant p-values. BIP167 was analyzed for allele sharing at the simple sequence repeat loci and significant associations were not found. At present we conclude, that the pedigrees under study do not have a major predisposition gene for bipolar affective disorder on chromosome 6 under the diagnostic and transmission models analyzed by the 2 different methods.
D S Gerhard; M C Labuda; D Marshall; K Otten; T Reich; R D Todd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  DNA sequence : the journal of DNA sequencing and mapping     Volume:  8     ISSN:  1042-5179     ISO Abbreviation:  DNA Seq.     Publication Date:  1997  
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9107800     Medline TA:  DNA Seq     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Bipolar Disorder / genetics*
Chromosome Mapping
Chromosomes, Human, Pair 6 / genetics*
Grant Support

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