| The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1. | |
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MedLine Citation:
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PMID: 19829069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genomic DNA is packed into a highly condensed chromatin structure, which acts as natural barrier preventing accessibility of DNA. In various processes to maintain genomic integrity such as DNA replication, DNA repair, telomere regulation, proteins need to overcome the barrier of condensed chromatin to gain access to DNA. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin. However, the chromatin remodeling complex does not contain intrinsic specificity for particular nuclear process, and the mechanism mediating its recruitment to DNA lesions remains to be an outstanding question. To address this question, in this review, we will discuss our current findings and future perspectives about how BRIT1/MCPH1, a human disease gene, specifies the function of chromatin remodelers and links chromatin remodeling to genome maintenance. |
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Authors:
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Guang Peng; Shiaw-Yih Lin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-10-08 |
Journal Detail:
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Title: Epigenetics : official journal of the DNA Methylation Society Volume: 4 ISSN: 1559-2308 ISO Abbreviation: Epigenetics Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-02-03 Revised Date: 2012-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101265293 Medline TA: Epigenetics Country: United States |
Other Details:
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Languages: eng Pagination: 457-61 Citation Subset: IM |
Affiliation:
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Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatin Assembly and Disassembly* DNA / genetics, metabolism DNA Repair Genetic Linkage* Genome, Human* Humans Nerve Tissue Proteins / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA112291/CA/NCI NIH HHS; R01CA112291/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MCPH1 protein, human; 0/Nerve Tissue Proteins; 9007-49-2/DNA |
| Comments/Corrections | |
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