Document Detail

The link between high-fat meals and postprandial activation of blood coagulation factor VII possibly involves kallikrein.
MedLine Citation:
PMID:  10757453     Owner:  NLM     Status:  MEDLINE    
Contrary to low-fat meals, high-fat meals are known to cause postprandial factor VII (FVII) activation, but the mechanism is unknown. To study the postprandial FVII activation in detail, 18 young men consumed in randomized order high-fat or low-fat test meals. Fasting and non-fasting blood samples were collected. The high-fat test was associated with an increase in plasma triglyceride and kallikrein concentrations and postprandial FVII activation (p<0.001). Plasma kallikrein was strongly associated with triglycerides in fasting and non-fasting samples (r2=0.74-0.87, p<0.0001), suggesting that triglyceride-rich lipoproteins may activate prokallikrein. Neither plasma triglycerides nor kallikrein and activated FVII were statistically associated. This may suggest that additional factors are involved in the postprandial FVII activation. No clear evidence for a role of tissue factor expression by monocytes, factor XII or insulin in postprandial FVII activation was observed. Tissue factor pathway inhibitor and prothrombin fragment 1+2, a marker of thrombin generation, were not affected postprandially after either the high-fat or the low-fat meals. Our findings indicate that triglyceride-rich lipoproteins activate prokallikrein postprandially, which might form an important initial event in FVII activation after consumption of high-fat meals.
L F Larsen; P Marckmann; E M Bladbjerg; P B Ostergaard; J Sidelmann; J Jespersen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  60     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-31     Completed Date:  2000-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  45-54     Citation Subset:  IM    
Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
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MeSH Terms
Blood Coagulation / drug effects,  physiology*
Blood Glucose
Dietary Fats / administration & dosage*
Enzyme Precursors / blood
Factor VII / analysis,  metabolism*
Factor XII / analysis,  metabolism
Factor XIIa / analysis,  metabolism
Insulin / blood
Kallikreins / blood*
Monocytes / metabolism
Peptide Fragments / analysis
Postprandial Period*
Prothrombin / analysis
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Fats; 0/Enzyme Precursors; 0/Peptide Fragments; 0/Triglycerides; 0/prothrombin fragment 1.2; 11061-68-0/Insulin; 9001-25-6/Factor VII; 9001-26-7/Prothrombin; 9001-30-3/Factor XII; EC 3.4.21.-/Kallikreins; EC 3.4.21.-/prokallikrein, tissue; EC XIIa

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