Document Detail

The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma.
MedLine Citation:
PMID:  6131223     Owner:  NLM     Status:  MEDLINE    
There are two apparently conflicting theories on the pathogenesis of exercise-induced asthma. One view is that exercise-induced asthma is directly related to respiratory heat exchange and that mast cells are not involved. The other theory explains exercise-induced asthma on the basis of a temperature-independent release of mast-cell mediators. A theory is put forward here that airway cooling in asthmatic subjects during exercise leads directly to mast-cell degranulation and that this explains the association between exercise, respiratory heat exchange, and mediator release.
T H Lee; B K Assoufi; A B Kay
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  520-2     Citation Subset:  AIM; IM; S    
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MeSH Terms
Asthma / etiology*
Asthma, Exercise-Induced / etiology*,  physiopathology
Chemotactic Factors, Eosinophil / metabolism
Hot Temperature
Hyperventilation / physiopathology
Mast Cells / immunology,  metabolism*
Models, Biological
Physical Exertion*
Reg. No./Substance:
0/Chemotactic Factors, Eosinophil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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