Document Detail

The limitless role of p53 in cell cycle machinery: good news or bad news?
MedLine Citation:
PMID:  16969127     Owner:  NLM     Status:  MEDLINE    
The p53 tumor suppressor gene acts as a great protagonist in deciding how cells undergo either cell cycle arrest or apoptosis after experiencing various stress signals, including DNA damage, hypoxia, oncogene activation, and hyperproliferation. Research on p53 is in steady expansion, as evidenced by the continual flood of papers claiming novel mutations, gain or loss of p53 functions, and gene interactions. The latest study carried out by Spurgers of Texas University and his Colleagues (J Biol Chem 2006; 281:25134-42) emphasizes the strong impact of p53 in the complicated machinery that regulates cell cycle progression. In this paper, microarray data and well-evaluated statistical procedures on PC3 and LNCaP prostate carcinoma cells, open new perspectives in p53 mechanisms and bring the simultaneous identification of novel p53-repressed cell cycle genes, hopefully providing significant improvements in the study of DNA damage response, multistep carcinogenesis, and treatment rationales and outcomes.
Paraskevi Vogiatzi; Marco Cassone; Giovanni Abbadessa; Pier Paolo Claudio
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Publication Detail:
Type:  Journal Article     Date:  2006-09-26
Journal Detail:
Title:  Cancer biology & therapy     Volume:  5     ISSN:  1538-4047     ISO Abbreviation:  Cancer Biol. Ther.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137842     Medline TA:  Cancer Biol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1090-3     Citation Subset:  IM    
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvannia, USA.
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MeSH Terms
Cell Cycle / physiology*
Genes, p53 / physiology*
Microarray Analysis
Tumor Suppressor Protein p53 / physiology*
Reg. No./Substance:
0/Tumor Suppressor Protein p53

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