Document Detail

The limited utility of routine cardiac stress testing in emergency department chest pain patients younger than 40 years.
MedLine Citation:
PMID:  19231025     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: This is a study designed to evaluate the utility of routine provocative cardiac testing in low-risk young adult (younger than 40 years) patients evaluated for an acute coronary syndrome in an emergency department (ED) setting. METHODS: This was a retrospective observational study of patients aged 23 to 40 years who were evaluated for acute coronary syndrome in an ED-based chest pain unit from March 2004 to September 2007. All patients had serial cardiac biomarker testing to rule out myocardial infarction and then underwent provocative cardiac testing to identify the presence of myocardial ischemia. Patients were excluded from the study if they had known coronary artery disease, had ECG findings diagnostic of myocardial infarction or ischemia, or self-admitted, or tested positive for cocaine use. RESULTS: Of the 220 patients who met inclusion criteria, 6 patients (2.7%; 95% confidence interval 1% to 5.8%) had positive stress test results. Among these 6 patients, 4 underwent subsequent coronary angiography that demonstrated no obstructive coronary disease, suggesting the initial provocative study was falsely positive. For the remaining 2 patients, no diagnostic angiography was performed. Discounting the patients who had negative angiography results, only 2 of 220 study patients (0.9%; 95% confidence interval 0.1% to 3.2%) had a provocative test result that was positive for myocardial ischemia. CONCLUSION: In our study, a combination of age younger than 40 years, nondiagnostic ECG result, and 2 sets of negative cardiac biomarker results at least 6 hours apart identified a patient group with a very low rate of true-positive provocative testing. Routine stress testing added little to the diagnostic evaluation of this patient group and was falsely positive in all patients who consented to diagnostic coronary angiography (4 of 6 cases).
Luke K Hermann; Scott D Weingart; W Lane Duvall; Milena J Henzlova
Related Documents :
16354605 - Symptoms and signs of an acute myocardial ischemia caused by chemotherapy with paclitax...
8227785 - Severity and response of chest pain during thrombolytic therapy for acute myocardial in...
10804595 - The emergency department experience of chest pain patients and their intention to delay...
8683855 - Vasospastic angina in patients with systemic triglyceride storage disease with jordans'...
19155075 - The relationship between tumor necrosis factor-α, brain natriuretic peptide and atrial...
12393065 - Calcium channel blockade limits transcriptional, translational and functional up-regula...
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-02-23
Journal Detail:
Title:  Annals of emergency medicine     Volume:  54     ISSN:  1097-6760     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-6     Citation Subset:  AIM; IM    
Department of Emergency Medicine, Division of Emergency Critical Care, Mount Sinai School of Medicine, New York, NY 10029, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Coronary Syndrome / diagnosis*,  epidemiology
Age Factors
Chest Pain / epidemiology*
Coronary Angiography / utilization
Diagnosis, Differential
Emergency Service, Hospital / statistics & numerical data*
Exercise Test / utilization*
False Positive Reactions
Predictive Value of Tests
Retrospective Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of EUS-guided fine needle aspiration and integrated PET-CT in restaging after treatment f...
Next Document:  When does age-related cognitive decline begin?