Document Detail

A limited comparison of apraclonidine's dose response in subjects with normal or increased intraocular pressure.
MedLine Citation:
PMID:  2672819     Owner:  NLM     Status:  MEDLINE    
We performed a multicentered, placebo-controlled, randomized, crossover study comparing the efficacy of 0.5% and 1.0% apraclonidine hydrochloride in 15 normal volunteers and 17 subjects with increased intraocular pressure. Apraclonidine 1% produced a maximum 30.4% +/- 14.0% (4.7 +/- 2.4 mm Hg) decrease in mean intraocular pressure in normal eyes and a 31.3% +/- 16.5% (7.6 +/- 4.2 mm Hg) decrease in eyes with increased pressure. Apraclonidine 0.5% produced a maximum 25.8% +/- 9.7% (4.0 +/- 1.7 mm Hg) decrease in mean intraocular pressure in normal eyes and a 27.4% +/- 16.0% (6.8 +/- 4.5 mm Hg) decrease in eyes with increased pressure. There was no statistically significant difference in mean percent intraocular pressure lowering effect between the 0.5% and 1.0% apraclonidine concentrations. Most subjects treated with apraclonidine had a greater than or equal to 20% reduction in intraocular pressure from baseline. Twelve hours after instillation of apraclonidine, nine of the normal volunteers had an intraocular pressure of 10 mm Hg or less. Apraclonidine produced the same percent intraocular pressure decrease regardless of the initial level of intraocular pressure.
D A Abrams; A L Robin; A S Crandall; D R Caldwell; D B Schnitzer; I P Pollack; J E Rader; T A Reaves
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  108     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-05     Completed Date:  1989-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  230-7     Citation Subset:  AIM; IM    
Glaucoma Service, Sinai Hospital, Baltimore, MD.
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MeSH Terms
Circadian Rhythm
Clinical Trials as Topic
Clonidine / administration & dosage,  analogs & derivatives*,  therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Intraocular Pressure / drug effects*
Middle Aged
Multicenter Studies as Topic
Ocular Hypertension / drug therapy*
Random Allocation
Time Factors
Reg. No./Substance:
0/Placebos; 4205-90-7/Clonidine; 66711-21-5/apraclonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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