| The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010). | |
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MedLine Citation:
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PMID: 21367410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To reassess the predictive value of detecting sperm cells in men with AZFb or AZFb-c deletions. DESIGN: Retrospective analysis of previously reported men with AZFb or AZFb-c deletions and the addition of six new cases. SETTING: Fertility institution. PATIENT(S): Men with both sequence tagged site marker identification and testicular cytology/histology findings. INTERVENTION(S): Systematic review of reported men with microdeletions that included eligibility, data extraction and analysis. MAIN OUTCOME MEASURE(S): Availability of sperm cells for intracytoplasmic sperm injection (ICSI) in men with AZFb/AZFb-c microdeletions. RESULT(S): The average prevalences reported for AZFb, AZFb-c, partial AZFb, and partial AZFb-c in azoospermic men were 0.9%±0.07%, 2.7%±0.93%, 1.23%±0.9%, and 1%±0.6%, respectively. Sperm cells were identified in 7% and 3% of the 28 and 71 men with complete AZFb and AZFb-c and in 57% and 43% of the 14 and 7 men with partial AZFb and AZFb-c deletions, respectively. The likelihood of finding sperm cells in men with complete versus partial AZFb and AZFb-c deletions was significantly lower. As yet, no clinical or chemical pregnancy after ICSI in cases with complete AZFb/b-c microdeletions has been reported. CONCLUSION(S): Determining the extent of AZFb or AZFb-c deletions is critical considering the frequency and the reasonable prospect of finding sperm cells in partial AZFb/AZFb-c deletions. Referring men with complete AZFb/b-c microdeletions to testicular sperm extraction/ICSI programs should be revaluated. |
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Authors:
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Sandra E Kleiman; Leah Yogev; Ofer Lehavi; Ron Hauser; Amnon Botchan; Gedalia Paz; Haim Yavetz; Ronni Gamzu |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2011-03-01 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-20 Completed Date: 2011-06-21 Revised Date: 2011-12-14 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2005-12, 2012.e1-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ser@tasmc.health.gov.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Separation Female Gene Deletion* Gene Frequency Genetic Loci Genetic Testing / methods Humans Infertility, Male / genetics*, pathology Male Pregnancy Probability Protein Isoforms / genetics Retrospective Studies Seminal Plasma Proteins / genetics* Spermatogenesis / genetics, physiology Spermatozoa / pathology*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Protein Isoforms; 0/Seminal Plasma Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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