Document Detail


Is light-at-night a health risk factor or a health risk predictor?
MedLine Citation:
PMID:  19731106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 2007, the IARC (WHO) has classified "shift-work that involves circadian disruption" as potentially carcinogenic. Ample evidence leaves no doubt that shift-work is detrimental for health, but the mechanisms behind this effect are not well understood. The hormone melatonin is often considered to be a causal link between night shift and tumor development. The underlying "light-at-night" (LAN) hypothesis is based on the following chain of arguments: melatonin is a hormone produced under the control of the circadian clock at night, and its synthesis can be suppressed by light; as an indolamine, it potentially acts as a scavenger of oxygen radicals, which in turn can damage DNA, which in turn can cause cancer. Although there is no experimental evidence that LAN is at the basis of increased cancer rates in shiftworkers, the scenario "light at night can cause cancer" influences research, medicine, the lighting industry and (via the media) also the general public, well beyond shiftwork. It is even suggested that baby-lights, TVs, computers, streetlights, moonlight, emergency lights, or any so-called "light pollution" by urban developments cause cancer via the mechanisms proposed by the LAN hypothesis. Our commentary addresses the growing concern surrounding light pollution. We revisit the arguments of the LAN theory and put them into perspective regarding circadian physiology, physical likelihood (e.g., what intensities reach the retina), and potential risks, specifically in non-shiftworkers.
Authors:
Thomas Kantermann; Till Roenneberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chronobiology international     Volume:  26     ISSN:  1525-6073     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1069-74     Citation Subset:  IM    
Affiliation:
Institute for Medical Psychology, University of Munich LMU, Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Chronobiology Disorders*
Circadian Rhythm
Environmental Exposure
Humans
Light*
Neoplasms
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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