| The ligands of peroxisome proliferator-activated receptor (PPAR) gamma inhibit growth of human esophageal carcinoma cells through induction of apoptosis and cell cycle arrest. | |
| | |
MedLine Citation:
|
PMID: 15274302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study, we examined the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and the growth-inhibitory effects of Troglitazone and Pioglitazone, selective ligands for PPARgamma, using a series of human esophageal carcinoma cell lines (TE-1, -3, -7, -8, -12 and -13). PPARgamma expression was detected in all six human esophageal carcinoma cell lines. The esophageal carcinoma cell line TE-13 showed marked growth inhibition in response to Troglitazone and Pioglitazone. Flow cytometry performed on TE-13 cells exposed to Troglitazone showed that the cell cycle was arrested at the G1-phase. This result was confirmed by the finding of reduced cyclin D and cyclin E expression by Western blot analysis. DNA ladder formation was also detected, as was the induction of apoptosis-related proteins. Our results suggested that Troglitazone inhibited the growth of human esophageal carcinoma cell lines via G1 arrest and apoptosis and that PPARgamma ligands should be considered as possible target molecules in the treatment of human esophageal carcinomas. |
| | |
Authors:
|
Daisuke Fujii; Kazuhiro Yoshida; Kazuaki Tanabe; Jun Hihara; Tetsuya Toge |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Anticancer research Volume: 24 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2004 May-Jun |
Date Detail:
|
Created Date: 2004-07-27 Completed Date: 2004-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
|
Languages: eng Pagination: 1409-16 Citation Subset: IM |
Affiliation:
|
Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan. dai9318@hiroshima-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents
/
pharmacology* Apoptosis / drug effects*, genetics Blotting, Western Cell Cycle / drug effects Cell Cycle Proteins / biosynthesis Cell Division / drug effects Cell Line, Tumor Chromans / pharmacology* Esophageal Neoplasms / drug therapy*, genetics, metabolism, pathology Gene Expression Regulation, Neoplastic / drug effects Humans Ligands Receptors, Cytoplasmic and Nuclear / biosynthesis*, metabolism Thiazolidinediones / pharmacology* Transcription Factors / biosynthesis*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Cell Cycle Proteins; 0/Chromans; 0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/Thiazolidinediones; 0/Transcription Factors; 111025-46-8/pioglitazone; 97322-87-7/troglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selenium compounds regulate p53 by common and distinctive mechanisms.
Next Document: Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma.