Document Detail


The life span of erythrocytes transfused to preterm infants.
MedLine Citation:
PMID:  9212030     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was made to determine the life span of adult red cells transfused to early preterm infants. Nineteen very preterm infants (birth weight, 878.7 +/- 221 g; gestational age, 26.8 +/- 1.5 wk at birth) were sampled weekly after their last blood transfusion to determine the level (%) of fetal Hb in their circulation. Two microliters of blood were subjected to reverse phase HPLC to separate the alpha, beta, and gamma globin components of their Hbs. The percent of fetal Hb (HbF) was calculated as gamma/gamma + beta x 100. The life span of the adult erythrocytes transfused was defined as the time interval between the transfusion and when the percentage of HbF in the recipient's circulation returns to the HbF levels that exist in the infant's autologous red cells (the maximum post transfusion HbF level). Twelve of the 19 infants were followed until their autologous HbF levels were reached. Their mean adult red blood cell life span was 56.4 +/- 7 d (range: 46-68 d). The results obtained in this study imply that the number of days after a transfusion at which half the cells infused remain in the circulation in a preterm infant is about 30 d.
Authors:
H Bard; J A Widness
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  42     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-09     Completed Date:  1997-09-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Montreal, Research Center, Hôpital Sainte-Justine, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Erythrocyte Aging / physiology*
Erythrocyte Transfusion*
Fetal Hemoglobin / metabolism
Humans
Infant, Newborn
Infant, Premature / blood*
Time Factors
Grant Support
ID/Acronym/Agency:
P01 HL46925/HL/NHLBI NIH HHS; RR0059/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9034-63-3/Fetal Hemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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