Document Detail


The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery.
MedLine Citation:
PMID:  10776439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study was to evaluate the clinical usefulness of the lidocaine test, as an index of hepatic function, in the different fields of liver surgery. METHODS: The lidocaine (MEGX [monoethylglycinexylidide]) test, which was performed in 200 patients with different liver diseases and in 23 organ donors, was compared with common laboratory tests. The MEGX value was related to postoperative complications in patients who undergo liver resection and to the survival of patients with cirrhosis who are awaiting transplantation. In organ donors, the test was related to the outcome of patients who underwent transplantation. RESULTS: The MEGX value was significantly higher in patients without cirrhosis compared to patients with cirrhosis (77.8 +/- 25 ng/mL vs 35.6 +/- 30 ng/mL; P < .05); among patients with cirrhosis, there was a significant difference between those patients classified Child A and those classified Child B and C (43.3 +/- 25 ng/mL vs 11.5 +/- 7.1 ng/mL; P < .05). The patients classified Child A who underwent liver resection with MEGX value less than 25 ng/mL had a significantly higher rate of postoperative complications compared with other patients (P < .001). Patients with cirrhosis who were awaiting liver transplantation and who had a MEGX value of less than 10 ng/mL had a life expectancy of no longer than 1 year. CONCLUSIONS: The MEGX test is a reliable index of hepatic function. Patients carrying hepatocellular carcinoma with MEGX value of less than 25 ng/mL have a high risk of liver insufficiency after hepatic resection. Patients with decompensated cirrhosis who have an MEGX value of less than 10 ng/mL should undergo transplantation as soon as possible.
Authors:
G Ercolani; G L Grazi; R Callivà; F Pierangeli; M Cescon; A Cavallari; A Mazziotti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery     Volume:  127     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-08     Completed Date:  2000-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-71     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery and Transplantation, S. Orsola Hospital, University of Bologna, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Bilirubin / blood
Carcinoma, Hepatocellular / blood,  surgery*
Female
Hepatectomy
Humans
Lidocaine / analogs & derivatives*,  blood,  pharmacokinetics
Liver Cirrhosis / blood,  surgery
Liver Diseases / blood,  surgery*
Liver Neoplasms / blood,  surgery*
Liver Transplantation
Male
Middle Aged
Postoperative Complications / blood,  classification,  mortality
Predictive Value of Tests
Prothrombin Time
Quaternary Ammonium Compounds / blood
Serum Albumin / analysis
Tissue Donors
Waiting Lists
Chemical
Reg. No./Substance:
0/Quaternary Ammonium Compounds; 0/Serum Albumin; 137-58-6/Lidocaine; 635-65-4/Bilirubin; 7728-40-7/monoethylglycinexylidide; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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