| The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. | |
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MedLine Citation:
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PMID: 21481092 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To investigate the levels of nitric oxide (NO) and asymmetric dimethylarginine (ADMA) in all the rat endometriosis models. Material & Methods: Forty-one rats with endometriotic implants were divided into four groups (1 to 4) and administered infliximab, etanercept, letrozole and control, respectively. There were 11 rats in group 5 (normal). The size of implants, plasma ADMA and nitrate/nitrite (NO(x) ) levels and histological score were assessed. Results: In groups 1, 2 and 3, plasma ADMA levels were higher than groups 4 and 5, 296.8 ± 66.2, 285.9 ± 35.7, 200.3 ± 41.0, 125.3 ± 16.7, 111.3 ± 6.5 µmol/L, respectively, while NO(x) levels were lower than groups of control and normal 19.6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively. Conclusions: Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO(x) levels, and increased plasma ADMA levels. |
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Authors:
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Tuncer Cayci; Emin Ozgur Akgul; Yasemin Gulcan Kurt; Temel S Ceyhan; Ibrahim Aydin; Onder Onguru; Halil Yaman; Erdinc Cakir; Mehmet Yasar; Cumhur Bilgi; Kemal M Erbil |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-12 |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: - ISSN: 1341-8076 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology. |
Affiliation:
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Departments of Medical Biochemistry Obstetrics and Gynecology Pathology Emergency Medicine, Gulhane Military Medical Academy, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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