Document Detail

PCDD/F levels in plasma of a belgian population before and after the 1999 belgian PCB/DIOXIN incident.
MedLine Citation:
PMID:  17208274     Owner:  NLM     Status:  MEDLINE    
We evaluated the impact of the 1999 Belgian dioxin incident on the blood plasma polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels among 232 Belgian blood donors (74% men, mean age 47 years). The Red Cross made plasma samples from before the incident of these donors available. A second plasma sample was collected during the second half of 2000. The sum of the 17 PCDD/F congeners was significantly lower in 2000 compared to 1998 (417 pg/g fat versus 445 pg/g fat, respectively). This could be completely attributed to the significant decrease of OctaCDD (301 pg/g fat in 2000 versus 277 pg/g fat in 1998). Moreover a slight but significant decrease was observed for 2,3,7,8-TetraCDF and for 1,2,3,4,6,7,8-HeptaCDF. 1,2,3,7,8-PentaCDF and 2,3,4,7,8-PentaCDF however showed a slight but significant increase (respective levels in 1998 were 0.004 and 14.5 pg/g fat compared to 0.006 and 17.9 pg/g fat in 2000). Given their significantly higher presence in incident related food samples this increase can be attributed to the food contamination episode. However, the total toxicity remained unchanged (22.9 in 1998 versus 23.1 pg WHO-TEQ/g fat, p>0.05). Moreover the observed congener profiles and the total PCDD/F levels were similar to those of other European non-occupationally exposed populations. In conclusion, the 1999 PCB/dioxin incident was traceable in the plasma profiles (rise of the two specific PCDF congeners), but comparison of the results for both years indicates that the changes were too small to cause an adverse public health effect.
Noëmi Debacker; André Sasse; Nathalie van Wouwe; Leo Goeyens; Francis Sartor; Herman van Oyen
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-01-08
Journal Detail:
Title:  Chemosphere     Volume:  67     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-13     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  S217-23     Citation Subset:  IM    
Scientific Institute of Public Health, Rue J. Wytsmanstraat 14, 1050 Brussels, Belgium.
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MeSH Terms
Belgium / epidemiology
Benzofurans / blood*
Cohort Studies
Dioxins / blood*,  toxicity
Environmental Exposure / adverse effects*
Food Contamination*
Polychlorinated Biphenyls / blood*,  toxicity
Population Groups
Tetrachlorodibenzodioxin / analogs & derivatives*,  blood
Time Factors
Reg. No./Substance:
0/Benzofurans; 0/Dioxins; 0/Polychlorinated Biphenyls; 0/chlorinated dibenzofurans; 0/polychlorodibenzo-4-dioxin; 1746-01-6/Tetrachlorodibenzodioxin

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