| The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction. | |
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MedLine Citation:
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PMID: 20667590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to the circulation and their level in the plasma is altered in certain pathological conditions such as cancer, and also during pregnancy. We examined the circulating levels of a set of trophoblastic miRNAs, which we recently found to be regulated by hypoxia, in the plasma of pregnant women with fetal growth restriction (FGR). Pregnancy was associated with increased plasma levels of several placenta-specific miRNAs, compared to non-pregnant controls. Among pregnant women, the overall levels of miRNA species that we analyzed were increased by 1.84-fold (p < or = 0.01) in plasma of women with pregnancies complicated by FGR, but decreased in FGR placentas by 24% (p < or = 0.01) compared to values from uncomplicated pregnancies. Together, our results show that plasma concentration of miRNAs is regulated in pregnancy, and that FGR is associated with increased circulating miRNA levels, highlighting the need to explore plasma miRNAs as potential biomarkers for placental diseases. |
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Authors:
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J-F Mouillet; T Chu; C A Hubel; D M Nelson; W T Parks; Y Sadovsky |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-29 |
Journal Detail:
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Title: Placenta Volume: 31 ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-20 Revised Date: 2011-10-31 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
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Languages: eng Pagination: 781-4 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA. mouilletj@mwri.magee.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anoxia / metabolism* Female Fetal Growth Retardation / metabolism* Humans MicroRNAs / metabolism* Placenta / metabolism* Pregnancy |
| Grant Support | |
ID/Acronym/Agency:
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5M01RR00056/RR/NCRR NIH HHS; P01 HD030367-17/HD/NICHD NIH HHS; P01-HD30367/HD/NICHD NIH HHS; R21 HD053878-03/HD/NICHD NIH HHS; R21-HD053878/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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