Document Detail

The level of vascular endothelial cell growth factor, nitric oxide, and endothelin-1 was correlated with ovarian volume or antral follicle counts: a potential predictor of pregnancy outcome in IVF.
MedLine Citation:
PMID:  20370579     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to investigate the correlation between the concentrations of vascular endothelial cell growth factor (VEGF), nitric oxide (NO), or endothelin-1 (ET-1) in follicular fluid with antral follicle counts (AFCs) or ovarian volume in order to predict the outcome of in vitro fertilization (IVF). One hundred and thirty-one patients were enrolled in this study, and the pregnancy rate was 37.4%. The concentration of VEGF or NO was significantly increased, while the concentration of ET-1 in follicular fluid was decreased in the group who became pregnant (P < 0.05). The ovarian volume or AFC was significantly higher in groups that became pregnant (P < 0.05). In addition, the ovarian volume or AFC was positively correlated with the concentration of VEGF or NO and negatively correlated with the concentration of ET-1 in follicular fluid. Our data suggest that these correlations may be associated with the successful pregnancies through IVF.
M Zhao; C Chang; Z Liu; L M Chen; Q Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth factors (Chur, Switzerland)     Volume:  28     ISSN:  1029-2292     ISO Abbreviation:  Growth Factors     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000468     Medline TA:  Growth Factors     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Wuxi Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, PR China.
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MeSH Terms
Cell Count
Endothelin-1 / analysis*
Fertilization in Vitro*
Follicular Fluid / chemistry,  metabolism
Nitric Oxide / analysis*
Organ Size
Ovarian Follicle / chemistry,  cytology*,  growth & development*
Pregnancy Rate
Vascular Endothelial Growth Factor A / analysis*
Reg. No./Substance:
0/Endothelin-1; 0/Vascular Endothelial Growth Factor A; 10102-43-9/Nitric Oxide

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