Document Detail

The level of nickel in smoker's blood and urine.
MedLine Citation:
PMID:  15666455     Owner:  NLM     Status:  MEDLINE    
General population is exposed to nickel from various sources. Smoking presents a significant form of exposure. The research was conducted in period 2000--2003 in Institute of Public Health in Nis. The samples of tobacco and cigarettes (127 samples) were both domestic and imported, and samples of biological material (123 blood samples and 147 urine samples) were taken from occupationally unexposed persons (smokers and non-smokers). The analyses were performed by electrothermal atomization technique, by Perkin Elmer AAS M-1100. The results obtained, revealed a high content of nickel in cigarettes (2.32-4.20 mg/kg) and in tobacco (2.20-4.91 mg/kg) regardless of the kind and the origin of tobacco. Nickel content in the blood of smokers (0.01-0.42 microg/l, median 0.07 microg/l) was higher than in the blood of non-smokers (0.01-0.26 microg/l, median 0.06 microg/l) although this difference was not statistically significant (p>0.05). In the urine of smokers (<0.01-8.20 microg/l, median 1.20 microg/l) there was a significantly higher concentration of nickel than in the urine of non-smokers (<0.01-4.60 microg/l, median 0.50 microg/l), p<0.05. The exposure of smokers to nickel through tobacco smoke was high regardless of the kind and the origin of tobacco and cigarettes. The content of nickel in tissue fluids established by biomonitoring shows that smokers can be far more exposed to this carcinogenic substance than non-smokers and that health risks for smokers are higher in this context.
D Stojanović; D Nikić; K Lazarević
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Central European journal of public health     Volume:  12     ISSN:  1210-7778     ISO Abbreviation:  Cent. Eur. J. Public Health     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417324     Medline TA:  Cent Eur J Public Health     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  187-9     Citation Subset:  IM    
Medical Faculty of Nis, Institute of Public Health Nis, Nis, Serbia and Montenegro. dusica.s@eunet.yu
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MeSH Terms
Case-Control Studies
Nickel / blood*,  urine*
Smoking / adverse effects*,  metabolism
Statistics, Nonparametric
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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