| The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. | |
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MedLine Citation:
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PMID: 22458844 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is dependent on cell adhesion molecules. The integrins are a family of heterodimeric transmembrane cell adhesion molecules that are also signalling receptors. They are involved in many biological processes, including the development of metazoans, immunity, haemostasis, wound healing and cell survival, proliferation and differentiation. The leucocyte-restricted β2 integrins comprise four members, namely αLβ2, αMβ2, αXβ2 and αDβ2, which are required for a functional immune system. In this paper, the structure, functional regulation and signalling properties of these integrins are reviewed. |
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Authors:
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Suet-Mien Tan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioscience reports Volume: 32 ISSN: 1573-4935 ISO Abbreviation: Biosci. Rep. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-03-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102797 Medline TA: Biosci Rep Country: United States |
Other Details:
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Languages: eng Pagination: 241-69 Citation Subset: IM |
Affiliation:
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Division of Molecular Genetics and Cell Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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